Peptidase specificity

Specificity is only shown where there are at least ten known substrates for a peptidase. The brighter the shade of green the greater the preference at each position. Specificity is shown in terms of the following amino acid groups: aliphatic (Ile, Leu, Val), aromatic (Phe, Trp, Tyr), acidic (Asp, Glu), basic (Arg, His, Lys), small (Ala, Cys, Gly, Ser) and other (Asn, Gln, Met, Pro, Thr). Positions where no amino acid is possible (for example P4-P2 for an aminopeptidase or P2'-P4' for a carboxypeptidase) are shown with a grey background.

MEROPS IDPeptidase nameTotal cleavagesP4P3P2P1P1'P2'P3'P4'
A01.001pepsin A970
A01.002pepsin B25othersmallsmallaromaticbasicaliphatic
A01.003gastricsin50
A01.004BACE1 g.p. (Homo sapiens)25aliphaticaliphatic
A01.006chymosin20aliphaticsmallaromaticaliphaticother
A01.007renin10otheraromaticbasicaliphaticaliphaticaliphaticaromaticsmall
A01.008renin-23 
A01.009cathepsin D924
A01.010cathepsin E1596
A01.011penicillopepsin17smallbasicsmall
A01.012rhizopuspepsin249
A01.013mucorpepsin9 
A01.014candidapepsin SAP126aliphaticaliphaticacidicaliphaticaromaticaliphaticaliphatic
A01.015barrierpepsin1 
A01.016aspergillopepsin I157
A01.017endothiapepsin11
A01.018saccharopepsin14
A01.019polyporopepsin11aliphaticaromaticother
A01.020phytepsin62
A01.021plasmepsin (Plasmodium sp.)5 
A01.022plasmepsin-113aromatic
A01.023plasmepsin-215aliphaticaromaticsmall
A01.027trichodermapepsin1 
A01.030yapsin-146basicsmall
A01.031yapsin-216aromaticbasicbasicacidicsmallacidicsmall
A01.035yapsin-39 
A01.036axp peptidase (Yarrowia lipolytica)3 
A01.037canditropsin9 
A01.038candiparapsin5 
A01.040nepenthesin733
A01.041BACE2 g.p. (Homo sapiens)33
A01.042syncephapepsin18other
A01.043histoaspartic peptidase (Plasmodium falciparum)4 
A01.045nothepsin1 
A01.046napsin A7 
A01.051pepsin F3 
A01.053necepsin-1133
A01.054tick heme-binding aspartic proteinase (Rhipicephalus microplus)2 
A01.055Mername-AA047 peptidase1 
A01.056Yps1 protein (Schizosaccharomyces pombe)3 
A01.059plasmepsin-48 
A01.060candidapepsin SAP222aliphaticaliphaticacidicaliphaticaromaticaliphaticaliphatic
A01.061candidapepsin SAP321aliphaticaliphaticacidicaliphaticaliphaticaromaticaliphaticaliphatic
A01.064candidapepsin SAP622aliphaticaliphaticacidicaliphaticaliphaticaromaticaliphaticaliphatic
A01.067candidapepsin SAP917basic
A01.068necepsin-245
A01.069CDR1 peptidase (Arabidopsis-type)2 
A01.070pepsin A44 
A01.071pepsin A5 (Homo sapiens)10
A01.073nucellin1 
A01.075plasmepsin-5 (Plasmodium sp.)7 
A01.076Sapp2p peptidase (Candida parapsilosis)7 
A01.084yolk cathepsin (Boophilus sp.)17aliphaticaliphatic
A01.085candidapepsin SAP1016basic
A01.088pepsin (fish)2 
A01.089pregnancy-associated glycoprotein 21 
A01.093CAD3 peptidase (Musca domestica)2 
A01.094pregnancy-associated glycoprotein 121 
A01.095shewasin A (Shewanella amazonensis)5 
A01.096chlapsin1 
A01.097GPI-anchored aspartic peptidase (Saccharomyces-type)1 
A01.098ASP5 g.p. (Toxoplasma gondii)1 
A01.UPAsubfamily A1A unassigned peptidases1 
A02.001HIV-1 retropepsin1046
A02.002HIV-2 retropepsin30smallotheraromaticotheraliphaticaliphaticother
A02.004equine infectious anaemia virus retropepsin13smallotherotheraromaticotheraliphaticaliphaticother
A02.005bovine immunodeficiency virus retropepsin11otherothersmallother
A02.007feline immunodeficiency virus retropepsin28aliphaticaliphatic
A02.008murine leukemia virus-type retropepsin20smallotherotheraromaticotheraliphaticaliphaticother
A02.009Mason-Pfizer leukemia virus retropepsin18smallotherotheraromaticotheraliphaticaliphaticother
A02.010mouse mammary tumor virus retropepsin13smallotheraromaticotheraliphaticaliphaticother
A02.011human endogenous retrovirus K retropepsin100aliphatic
A02.012retropepsin (human T-cell leukemia virus)15otheraliphaticaliphaticotheraliphaticother
A02.013bovine leukemia virus retropepsin20smallotheraromaticotheraliphaticaliphaticother
A02.015Rous sarcoma virus retropepsin18smallotherotheraromaticotheraliphaticaliphaticother
A02.016intracisternal A-particle retropepsin7 
A02.020porcine endogenous retrovirus peptidase6 
A02.022Ty3 transposon peptidase5 
A02.024rabbit endogenous retrovirus endopeptidase1 
A02.061Ulysses retrotransposon retropepsin6 
A02.063walleye dermal sarcoma virus retropepsin25smallotherotheraliphaticother
A03.001cauliflower mosaic virus-type peptidase1 
A03.002bacilliform virus peptidase6 
A05.001thermopsin18
A08.001signal peptidase II5 
A09.001spumapepsin11basicaliphaticotherotheraliphaticother
A11.001Copia transposon peptidase9 
A11.003Ty1 transposon peptidase3 
A22.001presenilin 116aliphaticaliphaticaliphaticaliphaticaliphaticaliphatic
A22.003impas 1 peptidase6 
A22.004signal peptide peptidase-like protein 2B5 
A22.007signal peptide peptidase-like protein 2A5 
A22.015intramembrane aspartyl peptidase (Methanoculleus marisnigri JR1)8 
A24.001type 4 prepilin peptidase 116otherbasicsmallaromaticotheraliphaticaliphatic
A24.016FlaK peptidase6 
A24.017PibD peptidase18basicbasicsmallsmallsmallsmallaliphatic
A24.018EppA peptidase2 
A25.001gpr peptidase32otherbasicacidicaliphaticsmallsmallacidic
A26.001omptin54basicbasic
A26.002OmpP peptidase11aliphaticsmallsmallbasicbasicsmallsmallsmall
A26.003plasminogen activator Pla16basicbasicaliphatic
A26.004protein E (Salmonella sp.)2 
A26.005IcsP peptidase (Shigella flexneri)1 
A28.004skin SASPase15smallaromaticaliphaticaromaticotheraliphaticsmallother
A31.001HybD peptidase4 
A31.003HycI peptidase1 
A31.005hupW peptidase1 
A31.006FrxA peptidase1 
A32.002RC1339 g.p. (Rickettsia conorii)800
A36.001sporulation factor SpoIIGA4 
A37.001sso1175 g.p. (Sulfolobus solfataricus)6 
A39.001TseI g.p. (Aeromonas dhakensis)2 
A9G.010pycnoporopepsin8 
A9G.017acid peptidase (Cladosporium)8 
A9G.019acrocylindropepsin6 
A9G.020yapsin A9 
C01.001papain89otherotheracidic
C01.002chymopapain12aliphatic
C01.003caricain9 
C01.004glycyl endopeptidase3 
C01.005stem bromelain26
C01.006ficin17
C01.007actinidin19
C01.008asclepain A11
C01.009cathepsin V1654aliphatic
C01.010vignain80aliphaticotherotheracidic
C01.011calotropain1 
C01.013cathepsin X46
C01.017zingipain1 
C01.018cathepsin F7 
C01.019CC-I peptidase (Vasconcellea sp.)1 
C01.020CC-III peptidase (Vasconcellea-type)3 
C01.024endopeptidase-B (Hordeum-type)70otherother
C01.026ananain17
C01.027comosain13basicsmall
C01.028fruit bromelain4 
C01.029pseudotzain1 
C01.030crustapain10other
C01.032cathepsin L2956aliphatic
C01.033cathepsin L1 (Fasciola sp.)196
C01.034cathepsin S3126aliphatic
C01.035cathepsin O2 
C01.036cathepsin K2207aliphatic
C01.037cathepsin W4 
C01.038cathepsin P10basicaliphaticbasicsmallsmallbasicother
C01.040cathepsin H48
C01.041aleurain6 
C01.044SmCL2 peptidase4 
C01.046falcipain-2152
C01.049cathepsin B, plant form1 
C01.050histolysain11basicbasic
C01.057vinckepain-228aliphaticaliphaticbasic
C01.060cathepsin B634small
C01.061SmCB2 peptidase (Schistosoma-type)2 
C01.062cathepsin B-like peptidase (platyhelminth)55
C01.063falcipain-3126
C01.064RD21 peptidase20basic
C01.066CPL-1 peptidase (Caenorhabditis elegans-type)4 
C01.067insect 26/29 kDa peptidase6 
C01.068vitellogenic cathepsin B1 
C01.070dipeptidyl-peptidase I33
C01.071toxopain-13 
C01.072rhodesain11aromaticbasic
C01.073peptidase 1 (mite)29small
C01.074CPB peptidase17basicaliphaticbasicaromaticsmallbasicother
C01.075cruzipain65aliphaticsmallbasic
C01.076CPA peptidase2 
C01.077falcipain-12 
C01.079papain homologue (Theileria-type)5 
C01.081papain homologue (Dictyostelium-type)2 
C01.082Mername-AA287 peptidase3 
C01.083V-cath peptidase1 
C01.084bleomycin hydrolase (animal)19
C01.085bleomycin hydrolase (yeast)9 
C01.086aminopeptidase C22
C01.088oligopeptidase E8 
C01.089peptidase G4 
C01.092cathepsin L1 (arthropod-type)12
C01.093miltpain1 
C01.094giardain2 
C01.096melain G6 
C01.097phytolacain13
C01.098CPC peptidase9 
C01.099ervatamin B6 
C01.100cruzipain 226basicaliphaticbasicaromaticsmallbasicother
C01.101cathepsin B-like peptidase, nematode47
C01.113tetrain1 
C01.115fascipain B10basic
C01.116ervatamin C7 
C01.120Mername-AA249 peptidase2 
C01.124dipeptidylpeptidase I (Plasmodium-type)6 
C01.125Cwp84 peptidase2 
C01.127TsCL-1 peptidase2 
C01.128xylellain2 
C01.129cathepsin L3 (Fasciola sp.)72
C01.130CSCP3 peptidase (Clonorchis-type)56
C01.133CmCatB (Callosobruchus maculatus)-type peptidase1 
C01.137ervatamin A8 
C01.141GsCL1 peptidase (Gnathostoma spinigerum)1 
C01.142cathepsin L2 (Fasciola sp.)54
C01.143intestain D4 (Leptinotarsa decemlineata)1 
C01.144cathepsin B-like cysteine peptidase (Raphanus sativus)24basic
C01.145hieronymain I1 
C01.146hieronymain II1 
C01.147hieronymain III1 
C01.149TgCPL peptidase (Toxoplasma-type)7 
C01.150asclepain f (Asclepias fruticosa)5 
C01.152SmCL3 peptidase (Schistosoma-type)1 
C01.153araujiain (Araujia sp.)5 
C01.155EhCP4 peptidase (Entamoeba histolytica)2 
C01.157vivapain-4 (Plasmodium vivax)4 
C01.158asclepain cI (Asclepias curassavica)1 
C01.159asclepain cII (Asclepias curassavica)6 
C01.160morrenain b I (Morrenia brachystephana)3 
C01.161morrenain b II (Morrenia brachystephana)1 
C01.164CPXaC peptidase (Xanthomonas sp.)1 
C01.165TgCPC1 (Toxoplasma gondii)2 
C01.166SmCL1 peptidase (Schistosoma mansoni and similar)9 
C01.167Cwp13 (Clostridium difficile)1 
C01.168endopeptidase-A (Hordeum-type)20aliphaticotherotheracidic
C01.169SERA6 (Plasmodium sp.)1 
C01.170macrodontain8 
C01.171Pd_dinase (Parabacteroides distasonis)4 
C01.172endopeptidase (bacterium symbiont of Theonella swinhoei)2 
C01.984serine-repeat antigen (Plasmodium sp.)2 
C01.UPAsubfamily C1A unassigned peptidases1 
C02.001calpain-1430
C02.002calpain-2452
C02.004calpain-319
C02.007calpain-82 
C02.009calpain tra-31 
C02.014calpain A3 
C02.015calpain B4 
C02.018calpain-101 
C02.022Tpr peptidase (Porphyromonas gingivalis)1 
C02.028calpain-71 
C02.029calpain (Plasmodium-type)1 
C03.001poliovirus-type picornain 3C14smallothersmallother
C03.003cowpea mosaic comovirus-type picornain 3C6 
C03.004grapevine fanleaf-type nepovirus picornain 3C3 
C03.005hepatitis A virus-type picornain 3C8 
C03.007human rhinovirus 2-type picornain 3C6 
C03.008foot-and-mouth disease virus picornain 3C5 
C03.009cardiovirus picornain 3C9 
C03.011Coxsackievirus-type picornain 3C10smallaliphaticaromaticothersmallotherotheraliphatic
C03.012tomato ringspot nepovirus picornain 3C7 
C03.013human rhinovirus 14-type 3C peptidase3 
C03.014human enterovirus 71 3C peptidase10smallaliphaticothersmall
C03.015Plautia stali intestine virus picornain C34 
C03.016tomato marchitez virus 3C peptidase6 
C03.020enterovirus picornain 2A12aliphaticothersmall
C03.021rhinovirus picornain 2A12aliphaticothersmallother
C03.024rice tungro spherical virus-type peptidase2 
C03.025tomato black ring virus-type picornain5 
C04.001nuclear-inclusion-a peptidase (plum pox virus)10aliphaticaromaticbasicothersmall
C04.003tobacco vein mottling virus-type NIa peptidase13aliphaticbasicaromaticothersmallsmallotherbasic
C04.004tobacco etch virus NIa peptidase14aliphaticbasicaromaticothersmallsmallotherbasic
C04.008bean yellow mosaic virus-type NIa peptidase7 
C04.014potato virus A NIa peptidase7 
C05.001adenain26aliphaticsmallsmallsmall
C06.001potato virus Y-type helper component peptidase2 
C07.001chestnut blight fungus virus p29 peptidase1 
C08.001chestnut blight fungus virus p48 peptidase1 
C09.001sindbis virus-type nsP2 peptidase6 
C10.001streptopain27aliphatic
C10.002PrtT peptidase1 
C10.003periodontain2 
C10.004interpain A22basic
C101.001OTULIN peptidase1 
C102.001GtgE peptidase1 
C104.002PlyPy phage lysin1 
C105.001papain-like peptidase 1 alpha (simian hemorrhagic fever virus)2 
C106.001archaeosortase A (Haloferax volcanii )2 
C107.001alphamesonivirus 3C-like peptidase2 
C108.001Prp peptidase (Staphylococcus aureus)1 
C108.002bacteriophage Cp-1 orf13 protein1 
C11.001clostripain9 
C11.003PmC11 peptidase (Parabacteroides merdae)7 
C11.004fragipain (Bacteroides fragilis)2 
C11.005thetapain1 
C11.006clostripain-related protein (Bacteroides thetaiotaomicron)3 
C110.001kyphoscoliosis peptidase1 
C111.001coagulation factor XIIIa1 
C113.001IgdE peptidase (Streptococcus suis)8 
C115.001MINDY-1 protein1 
C118.001EspL g.p. (Escherichia coli)2 
C12.001ubiquitinyl hydrolase-L18 
C12.002ubiquitinyl hydrolase-YUH16 
C12.003ubiquitinyl hydrolase-L326aliphaticbasicsmallsmall
C12.004ubiquitinyl hydrolase-BAP11 
C12.005ubiquitinyl hydrolase-L51 
C12.008ubiquitinyl hydrolase UCH-D3 
C120.001mavirus processing peptidase4 
C121.001MINDY-4 peptidase1 
C124.001Lem27 (Legionella pneumophila)5 
C13.001legumain (plant beta form)15otheraliphatic
C13.002legumain (plant alpha form)9 
C13.004legumain, animal-type2266other
C13.005glycosylphosphatidylinositol:protein transamidase19smallsmallsmall
C13.006legumain (plant gamma form)1 
C13.007legumain, trematode-type6 
C13.008legumain, Blastocystis-type1 
C13.009butelase 112smallaromaticbasicotherbasicaliphaticaliphaticsmall
C13.A01legumain (plant delta form)1 
C14.001caspase-1189acidicsmall
C14.002CED-3 peptidase14acidicacidicsmall
C14.003caspase-3700acidicacidicsmall
C14.004caspase-7501acidicsmall
C14.005caspase-61307acidicsmall
C14.006caspase-2290acidicsmall
C14.007caspase-411acidicacidicsmall
C14.008caspase-54 
C14.009caspase-872acidicsmall
C14.010caspase-914acidicacidicsmall
C14.011caspase-1010acidicacidicsmall
C14.012caspase-119 
C14.013caspase-125 
C14.015caspase (insect 1)8 
C14.016caspase (insect 2)3 
C14.018caspase-1417acidicsmall
C14.019caspase DRONC (Drosophila melanogaster)11acidicotheracidic
C14.022caspase DECAY8 
C14.024Mername-AA065 peptidase1 
C14.025caspase DAMM (Drosophila sp.)4 
C14.026paracaspase17aliphaticaliphaticsmallbasicsmall
C14.030Caspy peptidase (Brachydanio rerio-type)2 
C14.031Caspy2 g.p. (Brachydanio rerio)1 
C14.033metacaspase-4 (Arabidopsis-type)7 
C14.034metacaspase-9 (Arabidopsis-type)5 
C14.035metacaspase Yca1 (Saccharomyces cerevisiae-type)11basic
C14.036metacaspase mcII-Pa (Picea abies)-like peptidase3 
C14.037SfAV caspase (Spodoptera frugiperda ascovirus)1 
C14.038caspase-155 
C14.040caspase Dredd4 
C14.043metacaspase Ld (Leishmania-type)27basic
C14.044metacaspase TbMCA211basicsmallsmallother
C14.046metacaspase Atmc8 (Arabidopsis thaliana)2 
C14.047metacaspase-1 (Arabidopsis-type)9 
C14.049metacaspase Atmc5 (Arabidopsis sp.)9 
C14.050orthocaspase MaOC1 (Microcystis aeruginosa)9 
C14.A06csp-1 g.p. (Caenorhabditis elegans)7 
C15.001pyroglutamyl-peptidase I (prokaryote)3 
C15.010pyroglutamyl-peptidase I (chordate)6 
C15.012pyroglutamyl-peptidase I (Trypanosoma-type)4 
C16.001murine hepatitis coronavirus papain-like peptidase 14 
C16.002human coronavirus 229E papain-like peptidase 13 
C16.005avian infectious bronchitis coronavirus papain-like peptidase2 
C16.006mouse hepatitis coronavirus papain-like peptidase 22 
C16.009severe acute respiratory syndrome coronavirus papain-like peptidase3 
C16.010human coronavirus 229E papain-like peptidase 23 
C16.012coronavirus COVID-19 papain-like peptidase6 
C18.001hepatitis C virus peptidase 21 
C18.UPWfamily C18 unassigned peptidases1 
C19.001ubiquitin-specific peptidase 510aliphaticbasicsmallsmall
C19.002Ubp1 ubiquitin peptidase3 
C19.003Ubp2 ubiquitin peptidase3 
C19.004Ubp3 ubiquitin peptidase2 
C19.005Doa4 ubiquitin peptidase2 
C19.010ubiquitin-specific peptidase 412aliphaticbasicsmallsmall
C19.011ubiquitin-specific peptidase 86 
C19.012ubiquitin-specific peptidase 133 
C19.013ubiquitin-specific peptidase 29 
C19.014ubiquitin-specific peptidase 111 
C19.016ubiquitin-specific peptidase 712aliphaticbasicsmallsmallbasic
C19.017ubiquitin-specific peptidase 9X6 
C19.018ubiquitin-specific peptidase 103 
C19.019ubiquitin-specific peptidase 12 
C19.022ubiquitin-specific peptidase 1510aliphaticbasicsmallsmallother
C19.023ubiquitin-specific peptidase 171 
C19.024ubiquitin-specific peptidase 191 
C19.025ubiquitin-specific peptidase 202 
C19.028ubiquitin-specific peptidase 9Y2 
C19.030ubiquitin-specific peptidase 182 
C19.034ubiquitin-specific peptidase 212 
C19.037ubiquitin-specific peptidase 334 
C19.042ubiquitin-specific peptidase 361 
C19.046ubiquitin-specific peptidase 26 (Homo sapiens-type)1 
C19.047ubiquitin-specific peptidase 241 
C19.048ubiquitin-specific peptidase 421 
C19.052ubiquitin-specific peptidase 461 
C19.053ubiquitin-specific peptidase 372 
C19.054ubiquitin-specific peptidase 281 
C19.056ubiquitin-specific peptidase 381 
C19.057ubiquitin-specific peptidase 444 
C19.059ubiquitin-specific peptidase 351 
C19.060ubiquitin-specific peptidase 303 
C19.064ubiquitin-specific peptidase 451 
C19.065ubiquitin-specific peptidase 511 
C19.067ubiquitin-specific peptidase 343 
C19.073ubiquitin-specific peptidase 491 
C19.078USP17-like peptidase2 
C19.079ubiquitin-specific peptidase 6 (Saccharomyces-type)4 
C19.087ubiquitin-specific peptidase 8 (Saccharomyces cerevisiae)1 
C19.088ubiquitin-specific peptidase 10 (Saccharomycetales)1 
C19.094UBP6 peptidase (Arabidopsis-type)1 
C19.099UBP15 peptidase (Saccharomyces cerevisiae)8 
C19.100ubiquitin carboxyl-terminal hydrolase 13 (Saccharomyces cerevisiae)1 
C19.101ubiquitin carboxy-terminal hydrolase 7 (Saccharomyces cerevisiae)1 
C19.102putative ubiquitin carboxyl-terminal hydrolase ybl067c (Saccharomyces cerevisiae)1 
C19.103putative ubiquitin carboxyl-terminal hydrolase ybr058c (Saccharomyces cerevisiae)4 
C19.104ubpA (Dictyostelium discoideum)1 
C21.001tymovirus peptidase3 
C23.001carlavirus peptidase1 
C24.002feline calicivirus 3C-like peptidase8 
C24.003sapovirus 3C-like peptidase10aromaticacidicacidicsmallotherotheracidic
C25.001gingipain RgpA26basicsmall
C25.002gingipain K47basic
C25.003gingipain RgpB16basic
C26.001gamma-glutamyl hydrolase3 
C27.001rubella virus peptidase1 
C28.001foot-and-mouth disease virus L-peptidase7 
C28.002equine rhinovirus L-peptidase2 
C30.001coronavirus picornain 3C-like peptidase-144aliphaticothersmall
C30.002avian infectious bronchitis coronavirus 3C-like peptidase18aliphaticothersmall
C30.003human coronavirus 229E main peptidase14aliphaticothersmall
C30.004porcine transmissible gastroenteritis virus-type main peptidase4 
C30.005SARS coronavirus picornain 3C-like peptidase27aliphaticother
C30.007coronavirus COVID-19 3C-like peptidase16aliphaticothersmall
C30.UPWfamily C30 unassigned peptidases3 
C32.001equine arteritis virus-type cysteine peptidase5 
C32.002papain-like peptidase 1 beta (simian hemorrhagic fever virus)1 
C32.003papain-like peptidase 1 gamma (simian hemorrhagic fever virus)1 
C33.001equine arteritis virus Nsp2-type cysteine peptidase5 
C37.001calicivirin11aliphaticothersmallotheracidic
C37.003murine norovirus NS6 peptidase1 
C39.001bacteriocin-processing peptidase13aliphaticaliphaticsmallsmallsmall
C39.003streptococcin processing peptidase1 
C39.004mersacidin lantibiotic processing peptidase1 
C39.005colicin V processing peptidase1 
C39.007lacticin 481 processing peptidase (Lactococcus lactis)16aliphaticaliphaticsmallsmallbasicsmallsmallsmall
C40.001dipeptidyl-peptidase VI (bacteria)1 
C40.004spr peptidase2 
C40.005PgdS peptidase1 
C40.007YddH peptidase1 
C40.009NLP/P60 (Nostoc punctiforme)-like putative peptidase1 
C40.010CwlO peptidase (Bacillus sp.)1 
C40.011RipA peptidoglycan hydrolase4 
C40.012RipB peptidoglycan hydrolase3 
C40.013YdhO protein (Escherichia coli)1 
C40.014BacL1 peptidase (Enterococcus faecalis)1 
C42.001beet yellows virus-type papain-like peptidase1 
C42.003L1 peptidase (Citrus tristeza virus)1 
C42.004L2 peptidase (grapevine leafroll-associated virus 2)1 
C44.001amidophosphoribosyltransferase precursor1 
C45.001acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase precursor2 
C46.001hedgehog protein2 
C46.002Sonic hedgehog protein4 
C46.003Indian hedgehog protein2 
C46.004Desert hedgehog protein2 
C46.005Tiggy-winkle protein1 
C47.001staphopain A6 
C47.002staphopain B9 
C47.003EcpA peptidase8 
C47.004staphopain C10aliphaticaliphaticsmall
C48.001Ulp1 peptidase2 
C48.002SENP1 peptidase32otherothersmallsmallbasicacidic
C48.003SENP3 peptidase8 
C48.004SENP6 peptidase13otherothersmallsmallbasic
C48.007SENP2 peptidase20otherothersmallsmallbasic
C48.008SENP5 peptidase13otherothersmallsmallbasic
C48.009SENP7 peptidase2 
C48.011SENP8 peptidase8 
C48.023XopD peptidase3 
C48.031SENP8 peptidase (fungus-type)2 
C48.032ChlaDub1 peptidase2 
C48.034PfSENP1 (Plasmodium falciparum)2 
C48.A03At5g60190 (Arabidopsis thaliana)1 
C48.A04At1g60220 (Arabidopsis thaliana)1 
C48.A05At1g10570 (Arabidopsis thaliana)1 
C49.001Strawberry mottle virus 3C-like peptidase5 
C50.001separase (yeast-type)12acidicaliphaticsmallbasicsmallsmall
C50.002separase (Homo sapiens-type)3 
C50.003separase (Drosophila-type)1 
C51.001D-alanyl-glycyl peptidase (staphylococcal phage phi11-type)1 
C51.002bacteriophage B30 lysin3 
C53.001pestivirus Npro peptidase4 
C54.001ATG4 peptidase4 
C54.002autophagin-26 
C54.003autophagin-115smallotheraromaticsmall
C54.004autophagin-33 
C54.005autophagin-42 
C54.007ATG4.2 peptidase (Leishmania-type)2 
C54.008atg-4.1 peptidase (Caenorhabditis elegans-type)1 
C54.009atg-4.2 peptidase (Caenorhabditis elegans-type)1 
C54.010autophagin-2 (Trypanosoma cruzi)2 
C55.001YopJ protein4 
C56.001PfpI peptidase1 
C56.002DJ-1 putative peptidase1 
C56.006Hsp31 peptidase7 
C57.001vaccinia virus I7L processing peptidase4 
C58.001YopT peptidase3 
C58.002AvrPphB peptidase2 
C58.004NopT g.p. (Rhizobium sp. NGR234)1 
C58.005RipT g.p. (Ralstonia solanacearum GMI1000)1 
C58.007ORF4 g.p. (Pseudomonas syringae)1 
C59.001penicillin V acylase precursor1 
C60.001sortase A (Staphylococcus-type)21aliphaticotheracidicothersmall
C60.002sortase B5 
C60.003sortase C21 
C60.004sortase C (Bacillus-type)2 
C60.006sortase A (Streptococcus-type)9 
C60.007sortase C1 (Streptococcus sp.)1 
C62.001gill-associated virus 3C-like peptidase2 
C63.001African swine fever virus processing peptidase6 
C64.001Cezanne peptidase5 
C64.002Cezanne-2 peptidase1 
C64.003A20 peptidase3 
C64.004trabid peptidase8 
C64.006VCIP135 deubiquitinating peptidase2 
C65.001otubain-114aliphaticbasicsmallsmallbasic
C65.002otubain-22 
C66.001IdeS peptidase2 
C66.002dentipain2 
C67.001CylD peptidase7 
C69.001dipeptidase A2 
C69.002arginine aminopeptidase (Streptococcus-type)11basic
C70.001AvrRpt2 peptidase3 
C71.001pseudomurein endoisopeptidase Pei1 
C74.001pestivirus NS2 peptidase1 
C75.001AgrB peptidase1 
C76.001viral tegument protein deubiquitinylating peptidase4 
C78.001UfSP1 peptidase3 
C78.002UfSP2 peptidase2 
C78.003ZUP1 g.p. (Homo sapiens)3 
C78.004Mug105 (Saccharomyces pombe)3 
C79.001ElaD peptidase (Escherichia-type)3 
C80.001RTX self-cleaving toxin5 
C80.002self-cleaving toxin A (Clostridium-type)1 
C80.003self-cleaving toxin B (Clostridium-type)1 
C82.001L,D-transpeptidase (Enterococcus-type)1 
C82.002Ldt(fs) transpeptidase2 
C82.A01LdtF protein (Escherichia coli)1 
C83.001gamma-glutamylcysteine dipeptidyltranspeptidase1 
C83.002phytochelatin synthase1 
C84.001prtH peptidase (Tannerella forsythensis ATCC 43037)1 
C85.001OTUD5 peptidase (Homo sapiens)4 
C85.003OTUD3 peptidase (Homo sapiens)2 
C85.004OTUD1 peptidase (Homo sapiens)1 
C85.006OTU1 peptidase (Saccharomyces cerevisiae-type)3 
C85.007YOD1 peptidase4 
C85.008OTU2 peptidase (Saccharomyces cerevisiae-type)5 
C86.001ataxin-31 
C86.003ataxin-3 homologue (Caenorhabditis sp.)1 
C87.001nairovirus deubiquitinylating peptidase3 
C89.001acid ceramidase precursor1 
C89.002N-acylethanolamine acid amidase precursor1 
C93.001LapG peptidase (Pseudomonas fluorescens)1 
C95.001lysosomal 66.3 kDa protein (Mus musculus-type)2 
C96.001McjB peptidase1 
C97.001desumoylating isopeptidase 11 
C98.001USPL1 peptidase4 
C99.001iflavirus processing peptidase2 
C9B.001lysosomal dipeptidase II1 
C9C.001dipeptidyl-dipeptidase4 
C9G.001cathepsin N14
C9G.030bothropain12aromaticbasic
C9G.031protease-B-17N-1 (Bacillus sp. 17N-1)2 
G01.001scytalidoglutamic peptidase37basicaliphaticsmallsmallbasicother
G01.002aspergilloglutamic peptidase68
G01.005PMAP-1 peptidase (Penicillium marneffei)3 
G02.001pre-neck appendage protein (Bacillus phage phi29)1 
G03.001strawberry mottle virus glutamic peptidase2 
G04.001Tiki1 peptidase1 
G05.001RCE1 peptidase (Saccharomyces cerevisiae-type)4 
G05.002RCE1 peptidase (Homo sapiens-type)22basicotherbasicaliphaticaliphatic
G05.004microcystinase MlrA1 
G05.005RCE1 peptidase (Sarcomastigophora-type)1 
G06.001Ras/Rap1-specific peptidase2 
M01.001aminopeptidase N42
M01.002lysyl aminopeptidase (bacteria)22
M01.003aminopeptidase A14acidic
M01.004leukotriene A4 hydrolase21
M01.005alanyl aminopeptidase (bacterial-type)66
M01.006Ape2 aminopeptidase4 
M01.007Aap1' aminopeptidase1 
M01.008pyroglutamyl-peptidase II3 
M01.009aminopeptidase N (actinomycete-type)11
M01.010cytosol alanyl aminopeptidase57
M01.011cystinyl aminopeptidase11
M01.013aminopeptidase N (insect)14
M01.014aminopeptidase B16basic
M01.015aminopeptidase H11 (nematode)3 
M01.016aminopeptidase Ey18
M01.018endoplasmic reticulum aminopeptidase 180otheraliphaticother
M01.020tricorn interacting factor F26 
M01.021tricorn interacting factor F33 
M01.022arginyl aminopeptidase-like 114
M01.024ERAP2 aminopeptidase27
M01.025aminopeptidase-1 (Caenorhabditis-type)7 
M01.026aminopeptidase Q17
M01.028aminopeptidase O3 
M01.029M1 aminopeptidase (Plasmodium spp.)7 
M01.030aminopeptidase N2 (insect)1 
M01.031cold-active aminopeptidase (Colwellia psychrerythraea)-type peptidase2 
M01.032lysyl aminopeptidase 1 (Streptomyces sp.)8 
M01.033lysyl endopeptidase (Streptomyces albulus)1 
M01.034leukotriene A4 hydrolase (Saccharomyces cerevisiae)6 
M01.035LePepA g.p. (Legionella pneumophila)2 
M02.001angiotensin-converting enzyme peptidase unit 18 
M02.002peptidyl-dipeptidase Acer11aromaticaromatic
M02.003peptidyl-dipeptidase Ance7 
M02.004angiotensin-converting enzyme peptidase unit 213
M02.005peptidyl-dipeptidase A (Theromyzon-type)4 
M02.006angiotensin-converting enzyme-214other
M02.007peptidyl-dipeptidase A (Crassostrea-type)3 
M03.001thimet oligopeptidase124smallsmallotherother
M03.002neurolysin128smallsmallotheraromaticbasicother
M03.003saccharolysin8 
M03.004oligopeptidase A10other
M03.005peptidyl-dipeptidase Dcp8 
M03.006mitochondrial intermediate peptidase34othersmallbasic
M03.007oligopeptidase F24other
M03.009oligopeptidase MepB1 
M03.010Pz-peptidase A13otheraliphaticsmallother
M03.011tropolysin34smallaromaticsmallotheraromaticbasicother
M03.A12OCT1 (Arabidopsis thaliana)12smallsmall
M04.001thermolysin3994aliphatic
M04.003vibriolysin17small
M04.005pseudolysin70smallaliphatic
M04.006Msp peptidase (Legionella-type)8 
M04.007coccolysin25aliphatic
M04.008Mpl peptidase (Listeria sp.)1 
M04.009aureolysin24aliphatic
M04.010vimelysin12aliphatic
M04.011lambda toxin4 
M04.014bacillolysin41smallaliphaticsmall
M04.016PA peptidase (Aeromonas-type)2 
M04.017griselysin36smallaliphaticsmall
M04.018stearolysin5 
M04.019MprIII (Alteromonas sp. strain O-7)1 
M04.021neutral peptidase (Thermoactinomyces-type)1 
M04.024PrtS peptidase (Photorhabdus luminescens)1 
M04.025protealysin9 
M04.027Prt1 peptidase (Pectobacterium carotovorum)1 
M05.001mycolysin12aliphatic
M06.001immune inhibitor A peptidase (Bacillus sp.)24aliphatic
M06.002PrtV peptidase3 
M07.001snapalysin4 
M08.001leishmanolysin20aliphaticbasicbasic
M09.001collagenase V (Vibrio spp.)5 
M09.002collagenase G/A (Clostridium histolyticum)167smallsmallsmall
M09.003bacterial collagenase H246smallsmallother
M09.005collagenase ColT (Clostridium tetani)281smallsmall
M10.001matrix metallopeptidase-183aliphatic
M10.002matrix metallopeptidase-8114aliphaticsmall
M10.003matrix metallopeptidase-23417aliphatic
M10.004matrix metallopeptidase-9370smallsmall
M10.005matrix metallopeptidase-32468smallaliphatic
M10.006matrix metallopeptidase-10 (Homo sapiens-type)19other
M10.007matrix metallopeptidase-1121small
M10.008matrix metallopeptidase-7196aliphatic
M10.009matrix metallopeptidase-12218smallsmall
M10.010envelysin6 
M10.012GM1-MMP (Glycine max)3 
M10.013matrix metallopeptidase-13150othersmallaliphaticsmall
M10.014membrane-type matrix metallopeptidase-1136
M10.015membrane-type matrix metallopeptidase-214smallaliphaticother
M10.016membrane-type matrix metallopeptidase-320
M10.017membrane-type matrix metallopeptidase-427
M10.018matrix metallopeptidase-182 
M10.019matrix metallopeptidase-2043other
M10.020fragilysin5 
M10.021matrix metallopeptidase-198 
M10.022matrix metallopeptidase-23B1 
M10.023membrane-type matrix metallopeptidase-53 
M10.024membrane-type matrix metallopeptidase-6178
M10.025HMMP (Hydra vulgaris)-like peptidase1 
M10.029matrix metallopeptidase-2617otheraliphaticsmallaliphatic
M10.031Dm1 matrix metallopeptidase3 
M10.033collagenase-like A peptidase (rodent)1 
M10.036Dm2-matrix metallopeptidase1 
M10.038At5-MMP (Arabidopsis thaliana)169aliphatic
M10.039metallopeptidase II (Bacteroides fragilis)4 
M10.051serralysin2 
M10.053peptidase B (Erwinia-type)1 
M10.054peptidase C (Erwinia-type)1 
M10.056aeruginolysin13
M10.057mirabilysin32
M10.060epralysin10basicbasic
M10.063PrtA peptidase (Photorhabdus-type)29acidicaliphaticaromaticaliphatic
M10.066karilysin38othersmallaliphaticsmall
M10.A01At2-MMP (Arabidopsis thaliana)104aliphatic
M10.A02At4-MMP (Arabidopsis thaliana)183aliphaticsmall
M10.A04At1-MMP (Arabidopsis thaliana)61small
M10.A05At3-MMP (Arabidopsis thaliana)103
M101.001flagellinolysin2 
M102.001DA1 peptidase (Arabidopsis thaliana)1 
M103.001TldD peptidase (Escherichia coli)23
M11.001gametolysin7 
M12.001astacin209small
M12.002meprin alpha subunit776
M12.003myosinase2 
M12.004meprin beta subunit931acidic
M12.005procollagen C-peptidase41smallacidicacidicother
M12.006choriolysin L1 
M12.007choriolysin H7 
M12.008nephrosin6 
M12.010tolloid1 
M12.012blastula protease 10 (Paracentrotus)1 
M12.014hatching enzyme (Xenopus-type)6 
M12.015xolloid1 
M12.016vertebrate tolloid-like 1 protein17smallacidicacidic
M12.018mammalian-type tolloid-like 2 protein6 
M12.019MIG-17 peptidase1 
M12.020ADAM28 peptidase (mouse-type)5 
M12.021ADAMTS9 peptidase2 
M12.022brevilysin H62 
M12.025ADAMTS15 peptidase125small
M12.032LAST peptidase (Limulus-type)78smallother
M12.033LAST_MAM peptidase (Limulus-type)432
M12.066flavastacin25
M12.131acutolysin A2 
M12.132bilitoxin (Agkistrodon bilineatus)6 
M12.133fibrolase3 
M12.134halylysin a3 
M12.136leucolysin16smallaromatic
M12.137BHRa hemorrhagin (Bitis arietans)14
M12.138jararhagin40aliphatic
M12.139bothrolysin4 
M12.140bothropasin62aliphatic
M12.141adamalysin7 
M12.142atrolysin A8 
M12.143atrolysin B6 
M12.144atrolysin C60small
M12.145atrolysin E19smallaliphatic
M12.146atrolysin F6 
M12.147atroxase5 
M12.148basilysin5 
M12.149horrilysin5 
M12.150ruberlysin16small
M12.151ecarin4 
M12.152ophiolysin5 
M12.153fibrinolytic peptidase (Philodryas olfersii)15smallaliphaticaliphaticsmall
M12.154trimerelysin I8 
M12.155trimerelysin II12aliphaticaliphatic
M12.156trimerelysin IIA2 
M12.157mucrolysin14small
M12.158russellysin7 
M12.160venom metallopeptidase PREH3 
M12.161kistomin (Calloselasma rhodostoma)9 
M12.162mutalysin II7 
M12.164lebetase14
M12.167najalysin3 
M12.168alpha peptidase (Crotalus atrox)4 
M12.169metallopeptidase B (Bothrops moojeni)16basic
M12.170jararafibrase II (Bothrops jararaca)2 
M12.171HT-1 peptidase (Crotalus viridis)7 
M12.172carinactivase1 
M12.173mocarhagin4 
M12.175hemorrhagic toxin I (Crotalus ruber)5 
M12.177multactivase1 
M12.178brevilysin L616aliphaticaliphatic
M12.179bilitoxin 2 (Agkistrodon bilineatus)4 
M12.182hemorrhagic metallopeptidase a (Trimeresurus mucrosquamatus)4 
M12.183hemorrhagic metallopeptidase b (Trimeresurus mucrosquamatus)2 
M12.184mutalysin I2 
M12.188ADAMTS20 peptidase (mouse-type)1 
M12.190ammodytase6 
M12.191antarease70
M12.208ADAM8 peptidase23small
M12.209ADAM9 peptidase18smallsmallsmall
M12.210ADAM10 peptidase41small
M12.211Kuzbanian peptidase (non-mammalian)2 
M12.212ADAM12 peptidase2 
M12.214ADAM19 peptidase13smallsmall
M12.215ADAM15 peptidase2 
M12.216jerdohagin (Trimeresurus jerdonii)15
M12.217ADAM17 peptidase62aliphaticsmall
M12.219ADAMDEC1 peptidase4 
M12.220ADAMTS3 peptidase1 
M12.221ADAMTS4 peptidase506small
M12.222ADAMTS1 peptidase16aliphaticsmallacidicsmall
M12.224ADAM28 peptidase (Homo sapiens-type)6 
M12.225ADAMTS5 peptidase435small
M12.226ADAMTS8 peptidase1 
M12.236kaouthiagin2 
M12.241ADAMTS13 peptidase1 
M12.244ADAM33 peptidase4 
M12.301procollagen I N-peptidase4 
M12.303acutolysin C7 
M12.304jararafibrase III (Bothrops jararaca)5 
M12.305jararafibrase IV (Bothrops jararaca)2 
M12.306BHRb haemorrhagin (Bitis arietans)11aromatic
M12.307halylysin b6 
M12.308halylysin c8 
M12.309hemorrhagic toxin I (Gloydius halys blomhoffii)12smallaliphatic
M12.310metallopeptidase MTP-118
M12.311BaP1 peptidase (Bothrops asper)45aliphatic
M12.312neuwiedase (Bothrops neuwiedi)2 
M12.315halysase6 
M12.320hemorrhagic factor 3 (Bothrops jararaca)-like peptidase1 
M12.321TOH-2 peptidase1 
M12.327leucurolysin-a25
M12.334fibrinogenase-2 (Deinagkistrodon acutus)4 
M12.335baltergin (Bothrops alternatus)1 
M12.338BmooMPalpha-I (Bothrops sp.)36aromaticsmallotherbasicother
M12.345moojeni peptidase A10aliphaticsmall
M12.UPBsubfamily M12B unassigned peptidases9 
M13.001neprilysin124
M13.002endothelin-converting enzyme 134
M13.003endothelin-converting enzyme 217aromatic
M13.004oligopeptidase O110aliphaticaliphatic
M13.005oligopeptidase O37 
M13.008neprilysin-216aliphaticaromatic
M13.009Zmp1 peptidase (Mycobacterium-type)10aromatic
M13.010oligopeptidase O24 
M13.011MEP peptidase (nematode)57
M13.012Nep2 peptidase (insect)8 
M13.014neprilysin-4 (Drosophila melanogaster)32aromatic
M13.090Kell blood-group peptidase7 
M13.091PHEX peptidase51acidic
M14.001carboxypeptidase A117aromatic
M14.002carboxypeptidase A211aromatic
M14.003carboxypeptidase B7 
M14.004carboxypeptidase N15basic
M14.005carboxypeptidase E24basic
M14.006carboxypeptidase M11basic
M14.007carboxypeptidase T2 
M14.008gamma-D-glutamyl-(L)-meso-diaminopimelate peptidase I3 
M14.009carboxypeptidase B219basic
M14.010carboxypeptidase A37 
M14.011metallocarboxypeptidase D peptidase unit 11 
M14.012metallocarboxypeptidase Z14smallbasic
M14.014carboxypeptidase MeCPA5 
M14.016metallocarboxypeptidase D peptidase unit 21 
M14.017carboxypeptidase A468aliphatic
M14.018carboxypeptidase A642aliphatic
M14.020carboxypeptidase A51 
M14.023CPG70 carboxypeptidase (Porphyromonas gingivalis)27basic
M14.024insect gut carboxypeptidase-12 
M14.025cytosolic carboxypeptidase 56 
M14.027cytosolic carboxypeptidase 68 
M14.028cytosolic carboxypeptidase 117acidicacidicacidicacidic
M14.030cytosolic carboxypeptidase 45 
M14.031insect gut carboxypeptidase-22 
M14.032insect gut carboxypeptidase-34 
M14.034murein peptide amidase MpaA1 
M14.038PGP1 D,L-carboxypeptidase (Campylobacter jejuni)2 
M15.001zinc D-Ala-D-Ala carboxypeptidase (Streptomyces-type)1 
M15.002DD-carboxypeptidase pdcA (Myxococcus-type)1 
M15.003van XYc peptidase3 
M15.010vanY D-Ala-D-Ala carboxypeptidase5 
M15.011vanX D-Ala-D-Ala dipeptidase5 
M15.012Aad peptidase1 
M15.021Ply500 L-Ala-D-Glu peptidase1 
M15.022L-alanyl-D-glutamate peptidase (bacteriophage T5)1 
M15.023lysin LysA2 (Lactobacillus casei bacteriophage A2) and similar2 
M15.024DacB metallopeptidase (Streptococcus pneumoniae)2 
M16.001pitrilysin23
M16.002insulysin101
M16.003mitochondrial processing peptidase beta-subunit83basicsmall
M16.004chloroplast (stromal) processing peptidase19othersmall
M16.005nardilysin7 
M16.007Axl1 peptidase1 
M16.008Ste23 peptidase1 
M16.009eupitrilysin60
M16.011falcilysin10basicbasic
M16.013CYM1 peptidase (Saccharomyces cerevisiae)1 
M16.016YMXG peptidase40
M16.017plinsulysin17
M16.019YMXG peptidase5 
M17.001leucyl aminopeptidase 32 
M17.002leucyl aminopeptidase (plant-type)5 
M17.003PepA aminopeptidase3 
M17.004PepB aminopeptidase8 
M17.008M17 aminopeptidase (Plasmodium spp.)8 
M17.009aminopeptidase yspII (Schizosaccharomyces sp.)4 
M17.010leucyl aminopeptidase (Bacillus-type)2 
M17.011leucyl aminopeptidase (Fasciola-type)3 
M17.012PwLAP aminopeptidase2 
M17.013cysteinylglycinase (Treponema denticola)-like peptidase3 
M17.014LAPTc aminopeptidase1 
M17.015aminopeptidase pepZ (Staphylococcus sp.)16
M18.001aminopeptidase I1 
M18.002aspartyl aminopeptidase10acidic
M18.003aspartyl aminopeptidase (Plasmodium-type)3 
M19.001membrane dipeptidase4 
M19.003dipeptidase AC1 
M19.004membrane-bound dipeptidase-31 
M19.007thermostable dipeptidase (Brevibacillus-type)3 
M19.011dipeptidase 2 homologue (rodent)1 
M20.001glutamate carboxypeptidase1 
M20.002Gly-Xaa carboxypeptidase1 
M20.003peptidase T12smallsmallsmall
M20.004peptidase V6 
M20.005carnosine dipeptidase II6 
M20.006carnosine dipeptidase I17small
M20.007Xaa-His dipeptidase4 
M20.008carboxypeptidase Ss16 
M20.010DapE peptidase15acidic
M20.012Pep581 peptidase9 
M20.013Xaa-methyl-His dipeptidase13
M20.014indoleacetyl amino acid hydrolase1 
M20.017Dug1 peptidase1 
M20.020p-aminobenzoyl-glutamate hydrolase subunit A2 
M20.021cytosolic beta-alanyl-lysine dipeptidase6 
M23.001beta-lytic metallopeptidase15small
M23.002staphylolysin12smallsmallsmall
M23.003Mername-AA291 peptidase7 
M23.004lysostaphin6 
M23.005zoocin A1 
M23.008gp13 peptidase (bacteriophage phi-29)1 
M23.009Mername-AA292 peptidase2 
M23.010LytH peptidase1 
M23.011YebA peptidase1 
M24.001methionyl aminopeptidase 1 (Escherichia-type)978othersmall
M24.002methionyl aminopeptidase 2135othersmall
M24.003Xaa-Pro dipeptidase (bacteria-type)13other
M24.004aminopeptidase P (bacteria)9 
M24.005aminopeptidase P213otherother
M24.006bacillus Xaa-Pro aminopeptidase9 
M24.007Xaa-Pro dipeptidase (eukaryote-type)3 
M24.008hyperthermophile prolidase8 
M24.009aminopeptidase P118other
M24.017methionyl aminopeptidase 1 (eukaryote)6 
M24.026aminopeptidase P360aromaticsmallsmall
M24.028mitochondrial methionyl aminopeptidase131othersmall
M24.031leucine aminopeptidase (Thermotoga-type)4 
M24.032Mername-AA273 peptidase3 
M24.033aminopeptidase P (Streptomyces-type)12other
M24.034PH0974 dipeptidase7 
M24.036methionyl aminopeptidase 1 (Staphylococcus-type)3 
M24.037At4g36760 g.p. (Arabidopsis thaliana) and similar4 
M24.038aminopeptidase P (Plasmodium falciparum-type)22other
M24.039YdpF (Escherischia coli)19
M24.A14LCP55 (Arabidopsis thaliana)93aromaticsmallsmallsmall
M26.001IgA1-specific metallopeptidase1 
M27.001tentoxilysin4 
M27.002bontoxilysin10basic
M27.003VAMP-cleaving peptidase (Weissella oryzae)1 
M27.004botulinum neurotoxin X6 
M27.UPWfamily M27 unassigned peptidases2 
M28.001aminopeptidase Y28
M28.002aminopeptidase Ap166
M28.003aminopeptidase S (Streptomyces-type)10aliphaticaromatic
M28.004aminopeptidase AC13aromatic
M28.006Mername-AA063 peptidase19
M28.008secreted aminopeptidase (Pseudomonas-type)2 
M28.009YwaD peptidase5 
M28.010glutamate carboxypeptidase II10acidicacidic
M28.012glutamate carboxypeptidase III3 
M28.014carboxypeptidase Q33small
M28.015aminopeptidase ES-62 (Acanthocheilonema viteae)1 
M28.019aminopeptidase SSAP (Streptomyces septatus)9 
M28.020AM-1 aminopeptidase5 
M28.021AaaA aminopeptidase13basic
M28.022leucine aminopeptidase-1 (Aspergillus fumigatus)10
M29.001aminopeptidase T5 
M29.002aminopeptidase II (Bacillus-type)6 
M29.004PepS aminopeptidase1 
M29.005aminopeptidase S (Staphylococcus-type)2 
M30.001hyicolysin15aliphatic
M32.001carboxypeptidase Taq1 
M32.002carboxypeptidase Pfu2 
M32.003TcMCP1 carboxypeptidase27aromatic
M32.004TcMCP2 carboxypeptidase (Trypanosoma cruzi)1 
M32.005LmaCP1 carboxypeptidase (Leishmania major) and similar13small
M34.001anthrax lethal factor17basicotherotheraliphaticother
M34.002Pro-Pro endopeptidase 1 (Clostridium difficile-type)13aliphaticaliphaticotherotherotheraliphaticotherother
M34.003Pro-Pro endopeptidase 23 
M35.001penicillolysin36
M35.002deuterolysin27
M35.004peptidyl-Lys metallopeptidase2105basic
M36.001fungalysin6 
M36.002neutral protease I (Aspergillus oryzae)9 
M38.001isoaspartyl dipeptidase (metallo-type)3 
M38.002Pro-Hyp dipeptidase9 
M38.UPWfamily M38 unassigned peptidases3 
M41.001FtsH peptidase24
M41.003m-AAA peptidase2 
M41.006paraplegin1 
M41.013Ftsh peptidase (Thermus-type)32
M42.001glutamyl aminopeptidase (bacterium)7 
M42.002aminopeptidase I beta chain (Bacillus-type)2 
M42.003PhTET1 aminopeptidase12
M42.004PhTET2 aminopeptidase23
M42.005TET aminopeptidase12other
M42.008YpdE-type putative peptidase6 
M42.009PhTET3 aminopeptidase4 
M42.010CelM peptidase5 
M43.001cytophagalysin2 
M43.004pappalysin-14 
M43.005pappalysin-21 
M43.007ulilysin (Methanosarcina acetivorans)8 
M43.008Mername-AA293 peptidase1 
M44.001pox virus metallopeptidase1 
M48.001Ste24 peptidase6 
M48.003farnesylated-protein converting enzyme 14 
M48.018Oma1 peptidase1 
M48.020STE24 peptidase (Sarcomastigophora-type)1 
M48.021metallopeptidase PGM48 (Arabidopsis thaliana)6 
M49.001dipeptidyl-peptidase III25
M49.005Nudix hydrolase 36 
M49.006aflatoxin oxidase (Armillariella tabescens)2 
M49.007dipeptidyl-peptidase III (Caldithrix abyssi)10basic
M49.UPWfamily M49 unassigned peptidases2 
M50.001site 2 peptidase3 
M50.002sporulation factor SpoIVFB1 
M50.004RseP peptidase3 
M50.009At4g20310-like peptidase1 
M50.010PF0167 g.p. (Pyrococcus furiosus)1 
M50.UPBsubfamily M50B unassigned peptidases1 
M54.001archaelysin4 
M54.002aminopeptidase AMZ22 
M54.003aminopeptidase AMZ14 
M55.001D-aminopeptidase DppA8 
M56.001BlaR1 peptidase2 
M60.006ZmpB peptidase (Clostridium perfringens)6 
M61.001glycyl aminopeptidase26
M61.002BcepAP aminopeptidase (Burkholderia cepacia)10acidic
M64.001IgA peptidase (Clostridium ramosum-type)2 
M67.001PSMD14 peptidase2 
M67.002Csn5 peptidase4 
M67.006STAMBP isopeptidase2 
M67.009Mec peptidase1 
M72.001peptidyl-Asp metallopeptidase21acidic
M72.002CpaA g.p. (Acinetobacter baumannii)2 
M73.001camelysin11aliphatic
M74.001murein endopeptidase3 
M75.001imelysin8 
M76.002ATP23 peptidase (Saccharomyces cerevisiae-type)1 
M77.001tryptophanyl aminopeptidase 7-DMATS-type peptidase6 
M77.002tryptophanyl aminopeptidase FgaPT1 (Aspergillus fumigatus)6 
M77.003tryptophanyl aminopeptidase cdpNPT-type peptidase9 
M77.004tryptophanyl aminopeptidase FtmPT1-type peptidase9 
M78.001ImmA peptidase1 
M82.001PrsW peptidase1 
M85.001NleC peptidase (Escherichia coli)2 
M86.001PghP gamma-polyglutamate hydrolase (bacteriophage)1 
M87.001chloride channel accessory protein 16 
M87.002chloride channel accessory protein 46 
M87.003chloride channel accessory protein 25 
M87.004chloride channel accessory protein 7 (Mus musculus)1 
M87.005chloride channel accessory protein 4 (Mus musculus)1 
M87.006chloride channel accessory protein 1 (Mus musculus)1 
M87.UPWfamily M87 unassigned peptidases4 
M90.001MtfA peptidase5 
M91.001NleD peptidase (Escherichia coli-type)1 
M95.003selecase (Methanocaldococcus jannaschii)1 
M98.001YghJ g.p. (Escherichia coli)1 
M99.001Csd4 peptidase (Helicobacter pylori)1 
M9A.002tripeptide aminopeptidase1 
M9A.005clostridial aminopeptidase3 
M9A.007Xaa-Trp aminopeptidase35aromatic
M9A.008tryptophanyl aminopeptidase (Trichosporon cutaneum)15aromatic
M9A.009aminopeptidase X1 
M9A.011neuron-specific aminopeptidase10
M9A.012glycyl aminopeptidase (Actinomucor elegans)10small
M9A.013neuron-specific aminopeptidase-29 
M9B.001Xaa-Arg dipeptidase1 
M9B.004Met-Xaa dipeptidase14othersmall
M9D.001peptidyl-dipeptidase B5 
M9D.002proline-specific peptidyl-dipeptidase (Streptomyces)2 
M9E.002alanine carboxypeptidase3 
M9E.003mitochondrial carboxypeptidase1 
M9E.004membrane Pro-Xaa carboxypeptidase20other
M9E.007carboxypeptidase G312acidic
M9G.003acrolysin3 
M9G.005succinyl-tri-alanyl-p-nitroaniline hydrolase3 
M9G.009neutral endopeptidase (Aspergillus oryzae)6 
M9G.010FALGPA-peptidase (Treponema denticola)3 
M9G.018neutral endopeptidase (Micrococcus caseolyticus)12smallaromatic
M9G.021metallopeptidase QG (Escherichia coli)1 
M9G.022peptidase Ci (Escherichia coli)9 
M9G.025magnolysin1 
M9G.026dactylysin23
M9G.028magaininase4 
M9G.030dynorphin-processing endopeptidase (metallo-type)3 
M9G.031cyclic peptidase (Lactocobacillus)1 
M9G.034metallopeptidase ShpII (Staphylococcus hyicus)21aliphatic
M9G.036gonadotropin beta-subunit nicking enzyme1 
M9G.040hepatitis B virus binding factor1 
M9G.041aharin2 
M9G.047insulin-cleaving periplasmic peptidase (Acinetobacter calcoaceticus)7 
M9G.051ZPA-processing enzyme1 
M9G.054extracellular metallopeptidase (Pseudomonas fluorescens M3/6)1 
M9G.055dispase (Paenibacillus/Bacillus polymyxa)2 
N01.001nodavirus peptide lyase2 
N02.001tetravirus coat protein1 
N04.001Tsh-associated self-cleaving domain (Escherichia coli) and similar1 
N04.UPWfamily N4 unassigned peptide lyases1 
N06.001YscU protein1 
N06.002SpaS protein (Salmonella sp.)2 
N06.003EscU protein (Escherichia coli)1 
N06.004HrcU protein (Xanthomonas sp.)1 
N07.001reovirus type 1 coat protein1 
N08.001poliovirus capsid VP0-type self-cleaving protein40othersmallaliphaticothersmallotherotheraliphatic
N09.001intein-containing V-type proton ATPase catalytic subunit A45aliphaticaliphaticbasicothersmallacidicbasic
N10.002intein-containing replicative DNA helicase precursor160basicothersmallaliphatic
N10.003intein-containing DNA polymerase III subunit alpha precursor2 
N10.004intein-containing translation initiation factor IF-2 precursor51aliphaticbasicothersmallaliphaticother
N10.005intein-containing DNA polymerase II large subunit DP2 precursor Mername-AA28126basicothersmallaromaticother
N10.006intein-containing DNA polymerase II large subunit DP2 precursor Mername-AA28218basicbasicbasicsmallothersmallacidicaromaticsmallacidic
N10.007intein-containing DNA-dependent DNA polymerase precursor2 
N11.001intein-containing chloroplast ATP-dependent peptide lyase2 
P01.001DmpA aminopeptidase44small
P01.003BapF peptidase (Pseudomonas sp.)5 
P02.001EGF-like module containing mucin-like hormone receptor-like 21 
P02.010latrophilin-11 
P02.011latrophilin 31 
P02.038KIAA1879 protein1 
S01.001chymotrypsin A (cattle-type)1059aromatic
S01.005mast cell peptidase 4 (Rattus)40aliphaticaliphaticaromaticaromaticsmall
S01.010granzyme B (Homo sapiens-type)1902aliphaticacidic
S01.011testisin12smallotherbasic
S01.013Nudel peptidase1 
S01.015tryptase beta65basic
S01.017kallikrein-related peptidase 575basic
S01.019corin3 
S01.020kallikrein-related peptidase 1220basicaliphaticaliphaticsmall
S01.021DESC1 peptidase111basic
S01.023flavoxobin1 
S01.025mast cell peptidase 6 (mouse numbering)2 
S01.026mast cell peptidase 7 (mouse numbering)3 
S01.028tryptase gamma 15 
S01.029kallikrein-related peptidase 1479basic
S01.031peptidase 9 (Dermatophagoides-type)3 
S01.033factor VII-activating peptidase15basic
S01.034transmembrane peptidase, serine 410otherbasic
S01.035brachyurin-T2 
S01.039kallikrein 1-related peptidase b22 (Mus musculus)7 
S01.040chymotrypsin-like enzyme (Lepidoptera)1 
S01.041kallikrein 1-related peptidase b113 
S01.042intestinal serine peptidase (rodent)6 
S01.047human airway trypsin-like peptidase100basic
S01.052kallidin-releasing enzyme (Bitis arietans)6 
S01.069kallikrein 1-related peptidase b24 (Mus musculus)1 
S01.070kallikrein 1-related peptidase b26 (Mus musculus)1 
S01.071kallikrein 1-related peptidase b9 (Mus musculus)14basic
S01.072matriptase-3114basic
S01.073kallikrein 1-related peptidase b27 (Mus musculus)2 
S01.074marapsin3 
S01.075tryptase-65 
S01.079transmembrane peptidase, serine 31 
S01.081kallikrein-related peptidase 151380basic
S01.082spermosin (Halocynthia roretzi)1 
S01.08630kP peptidase A (Bombyx-type)8 
S01.087TMPRSS13 peptidase4 
S01.090hypodermin B5 
S01.094trypsin 1 (Rattus-type)3 
S01.095vascular chymase (Rattus norvegicus)6 
S01.096granzyme B (Equus-type)1 
S01.101trypsin (Streptomyces griseus-type)8 
S01.102trypsin (Streptomyces erythraeus-type)2 
S01.103trypsin (fungal)2 
S01.108tryptase-54 
S01.109astrovirus serine peptidase1 
S01.110trypsin alpha (insect)1 
S01.111hypodermin A4 
S01.112cocoonase6 
S01.113vitellin-degrading peptidase (Bombyx-type)1 
S01.118tryptase (mammalian, non-Homo sapiens-type)2 
S01.120trypsin-2 type B3 
S01.121hypodermin C8 
S01.122brachyurin-C36
S01.123euphauserase1 
S01.124trypsin Y2 
S01.125trypsin-1 (fish)4 
S01.126trypsin-3 (fish)1 
S01.127cationic trypsin (Homo sapiens-type)8 
S01.131elastase-2487aliphatic
S01.132mannan-binding lectin-associated serine peptidase-38 
S01.133cathepsin G465
S01.134myeloblastin55
S01.135granzyme A441basicsmall
S01.136granzyme B, rodent-type493aliphaticacidic
S01.137granzyme C19smallacidic
S01.139granzyme M1369aliphatic
S01.140chymase (Homo sapiens-type)107aromatic
S01.141mast cell peptidase 1 (Rattus-type)7 
S01.142duodenase19
S01.143tryptase alpha23basic
S01.144cercarial elastase (Schistosoma sp.)3 
S01.145mastin1 
S01.146granzyme K20basic
S01.147granzyme H8 
S01.149mast cell peptidase 4 (mouse numbering)11aromatic
S01.150mast cell peptidase 5 (mouse numbering)44aliphaticaliphaticaliphatic
S01.151trypsin 122991basic
S01.152chymotrypsin B26aromatic
S01.153elastase-151
S01.154pancreatic endopeptidase E3 
S01.155pancreatic elastase II19
S01.156enteropeptidase21acidicbasicsmallsmall
S01.157chymotrypsin C46
S01.159prostasin6 
S01.160kallikrein 131basic
S01.161kallikrein-related peptidase 266basicsmall
S01.162kallikrein-related peptidase 386
S01.163kallikrein 1-related peptidase b16 (Mus musculus)2 
S01.164kallikrein 1-related peptidase b13 
S01.165kallikrein 1-related peptidase c10 (Rattus norvegicus)5 
S01.167kallikrein 1 (Mus musculus)4 
S01.170kallikrein 1-related peptidase b33 
S01.172kallikrein 1-related peptidase c2 (Rattus norvegicus)21basic
S01.173kallikrein 13 (Mus musculus)7 
S01.174mesotrypsin22basic
S01.176batroxobin2 
S01.177crotalase2 
S01.178ancrod3 
S01.179bothrombin1 
S01.180platelet-aggregating venom peptidase4 
S01.181bilineobin1 
S01.183trypsin IV (Rattus norvegicus)3 
S01.184factor V activator (Daboia russellii)1 
S01.186snake venom plasminogen activator5 
S01.187peptidase 6 (Dermatophagoides sp.)2 
S01.188capillary permeability-increasing enzyme-2 (Gloydius-type)4 
S01.189complement component C1r-like peptidase1 
S01.191complement factor D3 
S01.192complement component activated C1r7 
S01.193complement component activated C1s20smallaliphaticsmallbasicaliphatic
S01.194complement component C2a9 
S01.196complement factor Bb8 
S01.198mannan-binding lectin-associated serine peptidase 18 
S01.199complement factor I7 
S01.200Snake peptidase (Insecta)1 
S01.201Easter peptidase1 
S01.204prophenoloxidase-activating peptidase-I1 
S01.211coagulation factor XIIa7 
S01.212plasma kallikrein40basic
S01.213coagulation factor XIa12otherbasicaliphaticsmall
S01.214coagulation factor IXa12smallbasic
S01.215coagulation factor VIIa9 
S01.216coagulation factor Xa63basic
S01.217thrombin195basicsmall
S01.218protein C (activated)15otherbasic
S01.219coagulation factor C (Limulus, Tachypleus), activated4 
S01.220coagulation factor B (Limulus, Tachypleus), activated4 
S01.221clotting enzyme (Tachypleus-type)4 
S01.222coagulation factor G, activated4 
S01.223acrosin6 
S01.224hepsin110basic
S01.228hepatocyte growth factor activator2 
S01.229mannan-binding lectin-associated serine peptidase 28 
S01.231urokinase-type plasminogen activator19smallbasic
S01.232t-plasminogen activator9 
S01.233plasmin132basic
S01.234peptidase 3 (Dermatophagoides-type)3 
S01.235acutobin3 
S01.236kallikrein-related peptidase 682basic
S01.237neurotrypsin2 
S01.239plasminogen activator (Desmodus-type)1 
S01.240ovochymase-23 
S01.243lumbrokinase25basic
S01.244kallikrein-related peptidase 825basic
S01.245ovochymase domain 31 
S01.246kallikrein-related peptidase 102 
S01.247epitheliasin8 
S01.251kallikrein-related peptidase 4123basic
S01.252prosemin2 
S01.253halystase6 
S01.256chymopasin6 
S01.257kallikrein-related peptidase 1116basicaliphaticsmall
S01.258trypsin-2 type A9 
S01.261streptogrisin A6 
S01.262streptogrisin B14smallaromatic
S01.265streptogrisin C1 
S01.266streptogrisin D5 
S01.267streptogrisin E23smallsmallacidicaliphaticaromaticacidic
S01.268alpha-lytic endopeptidase9 
S01.269glutamyl endopeptidase I4330acidic
S01.271glutamyl peptidase BL72smallacidic
S01.273DegP peptidase16aliphatic
S01.274DegQ peptidase7 
S01.275DegS peptidase6 
S01.276yeast-lytic peptidase5 
S01.277HtrA1 peptidase (Homo sapiens-type)5 
S01.278HtrA2 peptidase235aliphatic
S01.280lysyl endopeptidase (bacteria)809basic
S01.281arginyl peptidase11basicsmall
S01.282SplB peptidase (Staphylococcus aureus)19aromaticacidicaliphaticothersmallsmallother
S01.286Tysnd1 peptidase1 
S01.294HAT-like 3 peptidase11basic
S01.300kallikrein-related peptidase 743aromatic
S01.302matriptase119basic
S01.303mast cell peptidase-11 (rodent)6 
S01.305prophenoloxidase-activating peptidase (Bombyx-type)1 
S01.306kallikrein-related peptidase 1321basicaliphatic
S01.307kallikrein-related peptidase 91 
S01.308matriptase-2162basic
S01.311LCLP peptidase1 
S01.312SplE peptidase (Staphylococcus aureus)27aliphaticaromaticaliphaticbasicsmall
S01.313spinesin2 
S01.335calobin3 
S01.339cerastotin3 
S01.340serpentokallikrein-1 (Trimeresurus mucrosquamatus)1 
S01.346okinaxobin I3 
S01.347contortrixobin6 
S01.353KN-BJ peptidase 1 (Bothrops jararaca)7 
S01.356afaacytin (Cerastes cerastes)3 
S01.357polyserase-IA unit 111basic
S01.358polyserase-IA unit 22 
S01.364HtrA-like peptidase (Listeria-type)2 
S01.392allergen Sar s 35 
S01.405kallikrein 1 (Rattus sp.)10aromaticbasic
S01.407kallikrein 1-related peptidase c9 (Rattus sp.)14basic
S01.408elastase A4 
S01.409blarinasin7 
S01.412CHY1 peptidase (Metarhizium anisopliae)3 
S01.413prophenoloxidase-activating peptidase (Pacifastacus leniusculus)3 
S01.420prothrombin activator (Lonomia sp.)3 
S01.422fibrinolytic enzyme A (Annelida-type)19
S01.423SprE glutamyl peptidase3 
S01.425trocarin D4 
S01.428LV-Ka peptidase4 
S01.430gabonase (Bitis gabonica)4 
S01.431SFase-2 endopeptidase1 
S01.432rhombeobin (Lachesis muta rhombeata )4 
S01.433peptidase A (Bothrops-type)4 
S01.438fire ant chymotrypsin17otheraromatic
S01.443glutamyl peptidase BI14aliphaticacidic
S01.444hemolymph proteinase 142 
S01.446pseutarin C9 
S01.452blarina toxin (Blarina brevicauda)2 
S01.458chymase 1 (Mus musculus-type)44aromaticsmallaliphaticsmall
S01.462Spatzle-processing enzyme (Drosophila sp.)1 
S01.463LV-PA peptidase (Lachesis muta muta)2 
S01.464OET-03 peptidase (Homarus americanus)1 
S01.466ACC-C peptidase1 
S01.467hemolymph proteinase 212 
S01.479peptidase Ba III 4 (Bothrops atrox)1 
S01.480HtrA peptidase (Chlamydia trachomatis-type)14otheraliphaticother
S01.481harobin5 
S01.492venom serine peptidase (Hymenoptera)2 
S01.494Htra2 peptidase (Mycobacterium-type)39aliphatic
S01.499alkaline endopeptidase (Nesterenkonia sp.)9 
S01.501DEG15 peptidase2 
S01.503SplA peptidase (Staphylococcus aureus)23aromaticaromaticsmall
S01.515VesA peptidase (Vibrio cholerae)1 
S01.516VesB peptidase (Vibrio cholerae)1 
S01.517VesC peptidase (Vibrio cholerae)1 
S01.524kangshuanmei peptidase4 
S01.526SplD peptidase (Staphylococcus aureus)22aromaticaliphaticsmall
S01.527pepK (Porphyromonas gingivalis)1 
S01.529elastase-1 (Trichinella spiralis)1 
S01.975macrophage-stimulating protein1 
S01.UPAsubfamily S1A unassigned peptidases14basic
S03.001togavirin2 
S06.001IgA1-specific serine peptidase (Neisseria-type)6 
S06.002EspP peptidase (Escherichia coli)4 
S06.004Sat peptidase1 
S06.005Pic peptidase9 
S06.006Hap serine peptidase4 
S06.007IgA1-specific serine peptidase type 1 (Haemophilus sp.)3 
S06.008IgA1-specific serine peptidase type 2 (Haemophilus sp.)1 
S06.009EatA peptidase Mername-AA278 (Escherichia coli)6 
S07.001flavivirin29basicbasicsmall
S07.003Zika virus NS2B-NS3 peptidase2 
S08.001subtilisin Carlsberg43
S08.003subtilisin lentus16
S08.004wprA g.p. (Bacillus-type)1 
S08.005endopeptidase Q8 
S08.007thermitase13small
S08.008Mername-AA053 peptidase16
S08.009subtilisin Ak112
S08.010M-peptidase14
S08.012PfSUB1 peptidase23aliphaticsmallother
S08.013subtilisin-like peptidase 2 (Plasmodium-type)3 
S08.014ALE1 peptidase16
S08.017bacillopeptidase F9 
S08.019lactocepin I102
S08.020C5a peptidase2 
S08.022bpr peptidase (Dichelobacter nodosus)12
S08.023apr5 peptidase (Dichelobacter nodosus)6 
S08.024dentilisin17
S08.025allergen 13 (Penicillium sp.)2 
S08.027cell envelope peptidase A (Streptococcus-type)4 
S08.028high alkaline protease (Alkaliphilus transvaalensis)28
S08.029thermicin6 
S08.030IspA peptidase3 
S08.031bli-4 g.p. (Caenorhabditis sp.)4 
S08.032Psp3 peptidase4 
S08.034subtilisin BPN'17
S08.036subtilisin E4 
S08.037subtilisin DY16smallsmallotheraromatic
S08.039PCSK9 peptidase3 
S08.040apr2 peptidase (Dichelobacter nodosus)7 
S08.041perkinsin1 
S08.043HreP peptidase (Yersinia enterocolitica)1 
S08.046subtilisin aprM4 
S08.047KPC1-type peptidase2 
S08.048furin-1 (arthropod-type)6 
S08.049furin-2 (insect)4 
S08.050secreted peptidase A1 
S08.051aqualysin 111
S08.052cerevisin21
S08.053oryzin3 
S08.054endopeptidase K47
S08.056cuticle-degrading peptidase of parasitic fungus14
S08.057thermomycolin28
S08.059NisP (Lactococcus lactis)-type lantibiotic leader peptidase4 
S08.060EpiP lantibiotic leader peptidase1 
S08.061peptidase T1 
S08.063site-1 peptidase31basicbasicaliphaticaliphaticsmall
S08.065MutP (Streptococcus mutans)-type lantibiotic leader peptidase2 
S08.069SAM-P45 peptidase1 
S08.070kexin192basicbasic
S08.071furin216basicbasicbasic
S08.072PCSK1 peptidase97basicbasic
S08.073PCSK2 peptidase205basicbasic
S08.074PCSK4 peptidase103basicbasicbasic
S08.075PCSK6 peptidase105basicbasicbasic
S08.076PCSK5 peptidase129basicbasicbasic
S08.077PCSK7 peptidase116basicbasicbasic
S08.079PrcA peptidase4 
S08.085PepP lantibioYME1Ltic leader peptidase1 
S08.086CylA lantibiotic leader peptidase1 
S08.087EciP lantibiotic leader peptidase (Staphylococcus epidermidis)2 
S08.090tripeptidyl-peptidase II8 
S08.091tripeptidyl-peptidase S2 
S08.092cucumisin32
S08.093LasP lantibiotic leader peptidase (Lactobacillus sakei)1 
S08.095ElkP lantibiotic leader peptidase1 
S08.097peptidase C16 
S08.098subtilisin sendai6 
S08.099halophilic peptidase (Halobacillus sp. SR5-3)2 
S08.101halolysin 19 
S08.102halolysin R43 
S08.108CspB peptidase (Clostridium sp.)1 
S08.109KPC2-type peptidase115smallbasicbasicsmall
S08.110keratinase K1 (Stenotrophomonas maltophilia)8 
S08.112ARA12 peptidase53aromaticsmallotheraromaticsmallsmallsmall
S08.114peptidase Vpr (Bacillus-type)1 
S08.116lactocepin-3158
S08.120cuticle-degrading peptidase of nematode-trapping fungus3 
S08.121cytotoxin SubAB1 
S08.123KP-43 peptidase1 
S08.124ASUB peptidase3 
S08.125AspA (Aeromonas sobria)-type peptidase4 
S08.127TagC peptidase (Dictyostelium discoideum)2 
S08.129Tk-subtilisin1 
S08.130MCP-01 peptidase6 
S08.135tengconlysin19
S08.137AprX peptidase (Bacillus sp.)1 
S08.142collagenolytic endopeptidase (Geobacillus sp. MO-1)11
S08.145sporangin6 
S08.146PatG peptidase1 
S08.148keratinase (Doratomyces microsporus)19
S08.149CDF peptidase5 
S08.150phytaspase5 
S08.151SlSBT3 g.p. (Solanum lycopersicum)19
S08.153prtR peptidase (Lactobacillus rhamnosus)1 
S08.154SUB2 g.p. (Toxoplasma gondii)1 
S08.156PatA peptidase (Prochloron didemni )1 
S08.160NalP g.p. (Neisseria meningitidis)1 
S08.162EprS g.p. (Pseudomonas aeruginosa)12basic
S08.A21At5g59120 (Arabidopsis thaliana)2 
S09.001prolyl oligopeptidase59other
S09.002prolyl oligopeptidase homologue (Pyrococcus-type)3 
S09.003dipeptidyl-peptidase IV (eukaryote)29other
S09.004acylaminoacyl-peptidase14
S09.005dipeptidyl aminopeptidase A14other
S09.006dipeptidyl aminopeptidase B (fungus)7 
S09.007fibroblast activation protein alpha subunit6 
S09.008dipeptidyl peptidase 4 (Aspergillus-type)8 
S09.009dipeptidyl-peptidase 4 (bacteria-type 1)5 
S09.010oligopeptidase B42basic
S09.012dipeptidyl-peptidase 57 
S09.013dipeptidyl-peptidase 4 (bacteria-type 2)17other
S09.017prolyl tripeptidyl peptidase13othersmall
S09.018dipeptidyl-peptidase 810other
S09.019dipeptidyl-peptidase 915other
S09.021glutamyl endopeptidase C15acidic
S09.031AlbD protein (Pantoea dispersa)2 
S09.032sphingopyxin I lasso peptide isopeptidase10smallacidicacidicacidicother
S09.035lasso peptide isopeptidase (Asticcacaulis-type)1 
S09.036Rv0457c peptidase (Mycobacterium tuberculosis)2 
S09.057apsC g.p. (Aspergillus niger N400)3 
S09.069omega peptidase (Drosophila melanogaster)18acidicsmallother
S09.070acylaminoacyl peptidase (Aeropyrum-type)14aromatic
S09.072puromycin hydrolase17
S09.073Xaa-Pro dipeptidylpeptidase19aliphaticother
S09.075dipeptidyl-peptidase 5 (Porphyromonas sp.)7 
S09.076prolyl oligopeptidase (Myxococcus xanthus)2 
S09.077prolyl oligopeptidase B (Galerina marginata)3 
S09.078peptide cyclase 136otheraliphaticaromaticsmallaromaticothersmallbasic
S09.079S9dr carboxypeptidase (Deinococcus radiodurans)7 
S09.A02At1g76140 (Arabidopsis thaliana)-type peptidase1 
S09.UPAsubfamily S9A unassigned peptidases3 
S10.001carboxypeptidase Y17small
S10.002serine carboxypeptidase A10aromatic
S10.004serine carboxypeptidase C18small
S10.005serine carboxypeptidase D16small
S10.006Mername-AA083 peptidase72
S10.007kex carboxypeptidase9 
S10.008carboxypeptidase OcpA14small
S10.009serine carboxypeptidase III (plant)16small
S10.010serine carboxypeptidase Z (Absidia zachae) and similar16
S10.014carboxypeptidase O90
S10.UPWfamily S10 unassigned peptidases31
S11.001D-Ala-D-Ala carboxypeptidase A4 
S11.002murein-DD-endopeptidase1 
S11.004K15-type DD-transpeptidase2 
S11.006D,D-carboxypeptidase PBP3 (Streptococcus-type)1 
S11.007penicillin-binding protein 4 (Neisseria-type) peptidase2 
S11.008penicillin-binding protein 5-type peptidase7 
S11.011D-alanyl-D-alanine carboxypeptidase (Mycobacterium smegmatis)2 
S12.001D-Ala-D-Ala carboxypeptidase B11
S12.002aminopeptidase DmpB17
S12.003alkaline D-peptidase12
S12.008Pab87 peptidase1 
S12.009microcystinase MlrB1 
S12.012AmpH protein (Escherichia-type)2 
S12.013paenidase3 
S13.001D-Ala-D-Ala peptidase C1 
S13.002D-Ala-D-Ala carboxypeptidase (Actinomadura-type)9 
S13.004penillin-binding protein 41 
S13.005Bd3459 D-alanyl-D-alanine carboxypeptidase (Bdellovibrio bacteriovorus)1 
S14.001peptidase Clp (type 1)15smallotheraliphaticaliphaticother
S14.002peptidase Clp (type 2)1 
S14.003peptidase Clp (type 3)10smallothersmallaliphaticaliphaticother
S14.011PFC0310c peptidase1 
S15.001Xaa-Pro dipeptidyl-peptidase10smallother
S16.001Lon-A peptidase21
S16.002PIM1 peptidase8 
S16.007LonC peptidase2 
S16.012SepM peptidase (Streptococcus mutans)1 
S21.001assemblin5 
S21.002cytomegalovirus assemblin13aliphaticsmallsmall
S21.003Epstein-Barr virus-type assemblin4 
S21.004herpesvirus 6-type assemblin4 
S21.005Varicella zoster assemblin2 
S21.006herpesvirus 8-type assemblin2 
S24.001repressor LexA4 
S24.003UmuD protein1 
S24.UPWfamily S24 unassigned peptidases4 
S26.001signal peptidase I347smallsmallsmall
S26.002mitochondrial inner membrane peptidase 15 
S26.003signal peptidase SipS2 
S26.004signal peptidase SipT1 
S26.008thylakoidal processing peptidase52smallsmall
S26.010signalase (animal) 21 kDa component363smallsmall
S26.011signal peptidase SipW (Bacillus-type)1 
S26.012mitochondrial inner membrane peptidase 21 
S26.014TraF peptidase1 
S26.015Streptococcus-type signal peptidase6 
S26.016SpsB signal peptidase49othersmallbasicsmallsmall
S28.001lysosomal Pro-Xaa carboxypeptidase11other
S28.002dipeptidyl-peptidase II30other
S28.005PRO1 g.p. (Plasmodiophora brassicae)1 
S29.001hepacivirin6 
S30.001potyvirus P1 peptidase2 
S30.002clover yellow vein potyvirus-type P1 peptidase1 
S31.001pestivirus NS3 polyprotein peptidase4 
S32.001equine arteritis virus serine peptidase15acidicsmallsmall
S32.002porcine reproductive and respiratory syndrome virus nsp4 peptidase10aliphaticacidicsmallsmall
S33.001prolyl aminopeptidase6 
S33.002tripeptidyl-peptidase A5 
S33.004prolyl dipeptidase (Lactobacillus-type)18other
S33.005tricorn interacting factor F116smallsmallaromatic
S33.006tripeptidyl-peptidase B1 
S33.007tripeptidyl-peptidase C1 
S33.008prolyl aminopeptidase 210othersmall
S33.010SCO7095-type peptidase11basic
S33.021iminopeptidase I (Lactobacillus delbrueckii) and similar1 
S33.023Hip1 peptidase (Mycobacterium tuberculosis)5 
S37.001PS-10 peptidase3 
S39.001sobemovirus peptidase5 
S41.001C-terminal processing peptidase-19 
S41.002C-terminal processing peptidase-22 
S41.006tricorn core peptidase (bacteria)9 
S41.007ctpB peptidase18
S41.011chlamydial protease-like activity factor700small
S41.013CtpA peptidase (Borrelia-type)2 
S45.001penicillin G acylase precursor3 
S46.001dipeptidyl-peptidase 7 (Porphyromonas gingivalis-type)21
S46.002dipeptidyl-peptidase 11 (Porphyromonas gingivalis-type)10aliphaticacidic
S46.004BF9343_2924 g.p. (Bacteroides sp.)1 
S49.001signal peptide peptidase A (Pseudomonas aeruginosa)7 
S49.003protein C (bacteriophage lambda)1 
S49.005archaean signal peptide peptidase 17 
S50.001infectious pancreatic necrosis birnavirus Vp4 peptidase8 
S50.002avian infectious bursal disease birnavirus Vp4 peptidase5 
S50.003Drosophila X virus Vp4 peptidase2 
S50.004blotched snakehead birnavirus Vp4 peptidase38basicsmallsmallacidicsmallother
S51.001dipeptidase E7 
S51.003cyanophycinase1 
S53.001sedolisin22othersmallbasicaromaticbasicaliphatic
S53.002sedolisin-B47otheraliphaticacidicaromaticbasicaliphatic
S53.003tripeptidyl-peptidase I45
S53.004kumamolisin11aromaticaliphatic
S53.005kumamolisin-B61otheraliphaticacidicaromaticbasicaliphatic
S53.006physarolisin11aliphatic
S53.007aorsin10aliphaticbasicbasic
S53.009kumamolisin-As1 
S53.010grifolisin13
S53.011scytalidolisin20smallsmallsmall
S54.002rhomboid-like protein 21 
S54.004AarA peptidase58aliphaticsmallothersmallsmallaromaticsmallsmall
S54.007Pcp1 peptidase (yeast)2 
S54.009PARL peptidase3 
S54.014rhomboid YqgP peptidase4 
S54.016GlpG peptidase (Escherichia-type)7 
S54.017ROM4 peptidase (Plasmodium-type)1 
S55.001SpoIVB peptidase3 
S59.001nucleoporin 1451 
S59.002nuclear pore complex component Nup145 (Saccharomyces-type)1 
S59.A07nup189 (Schizosaccharomyces pombe)1 
S60.001lactoferrin7 
S60.972serotransferrin precursor (domain 1)4 
S65.001picornain-like serine peptidase (Breda-1 torovirus)2 
S66.001murein tetrapeptidase LD-carboxypeptidase (Pseudomonas-type)1 
S66.002murein tetrapeptidase LD-carboxypeptidase (Escherichia-type)6 
S68.001PIDD auto-processing protein unit 12 
S69.001Tellina virus 1 VP4 peptidase6 
S71.001MUC1 self-cleaving mucin1 
S72.001dystroglycan1 
S73.001gpO peptidase (Enterobacteria phage P2)1 
S74.001Escherichia coli phage K1F endosialidase CIMCD self-cleaving protein1 
S74.003myelin regulatory factor1 
S75.001White bream virus serine peptidase4 
S77.001prohead peptidase gp21 (bacteriophage T4)15aliphaticacidicsmall
S79.001CARD8 self-cleaving protein1 
S80.001prohead peptidase gp175 (Pseudomonas aeruginosa phage phiKZ)25smallacidic
S80.002SPN3US prohead peptidase ((Salmonella) myovirus)3 
S81.001destabilase4 
S82.001autocrine proliferation repressor protein A (Dictyostelium discoideum)1 
S85.001small protease (Pseudomonas aeruginosa)4 
S9F.001peptidyl-glycinamidase5 
S9G.012tryase14basicbasic
S9G.013guanidinobenzoatase1 
S9G.014clipsin2 
S9G.023ingobsin4 
S9G.025snake venom coagulation factor X activator, serine-type (Bungarus fasciatus, Cerastes vipera, Ophiophagus hannah)6 
S9G.031leucyl endopeptidase (Spinacia oleracea)2 
S9G.034metridin9 
S9G.038endopeptidase So1 
S9G.041peptidase V (Escherichia coli)7 
S9G.054profilaggrin endopeptidase 14 
S9G.055thermostable serine endopeptidase (Sulfolobus)2 
S9G.058beta-secretase Matsumoto2 
S9G.062thrombocytin4 
S9G.064archealysin8 
S9G.069apoptotic serine peptidase AP241 
S9G.087jerdonobin (Trimeresurus jerdonii)2 
S9G.088jerdofibrase (Trimeresurus jerdonii)4 
S9G.089flavovilase (Trimeresurus flavoviridis)2 
S9G.093MSP 1 endopeptidase (Bothrops moojeni)8 
S9G.094MSP 2 endopeptidase (Bothrops moojeni)8 
S9G.100okinaxobin II (Trimeresurus okinavensis)2 
S9G.103PofibS endopeptidase (Philodryas olfersii)5 
S9G.107seaprose (Aspergillus melleus)3 
S9G.111milin (Euphorbia milii)3 
S9G.114CP790 peptidase (Lactobacillus helveticus CP790)32other
S9G.116wrightin (Wrightia tinctoria)1 
S9G.117coagulant peptidase (Trimeresurus flavoviridis)3 
S9G.118Nysius proteinase11otherothersmallothersmallotherothersmall
S9G.119CLE-processing peptidase1 
T01.002archaean proteasome, beta component4 
T01.005bacterial proteasome, beta component1 
T01.006HslV component of HslUV peptidase3 
T01.007CodW component of CodWX peptidase1 
T01.010proteasome subunit beta1c43acidic
T01.011proteasome subunit beta2c32basic
T01.012proteasome subunit beta5c221
T01.013proteasome subunit beta1i1 
T01.015proteasome subunit beta5i1 
T01.018PfHslV peptidase3 
T01.021TbHslUV peptidase1 
T02.001glycosylasparaginase precursor9 
T02.002isoaspartyl dipeptidase (threonine type)17acidic
T02.004taspase-15 
T03.001gamma-glutamyltransferase 1 (bacterial-type)3 
T03.006gamma-glutamyltransferase 1 (mammalian-type)3 
T03.023CapD poly-gamma-glutamate hydrolase1 
T05.001ornithine acetyltransferase precursor1 
T05.002ArgJ protein (archea)1 
T07.001CwpV (Clostridium difficile) self-cleaving threonine peptidase1 
U40.001protein P5 murein endopeptidase (bacteriophage phi-6)1 
U49.001Lit peptidase1 
U69.001AIDA-I self-cleaving autotransporter protein (Escherichia coli)1 
U72.001Dop isopeptidase1 
U74.001neprosin110other
U9B.003Glu-Glu dipeptidase1 
U9B.004peptidyl-D-amino acid hydrolase (cephalopod)13small
U9B.005LD-dipeptidase (Bacillus sphaericus)8 
U9C.001dipeptidylaminopeptidase dDAP3 
U9F.002N-formylmethionyl-peptidase3 
U9G.007dibasic processing endopeptidase (unsequenced)9 
U9G.008leulysin2 
U9G.012peptidase yscJ2 
U9G.029prolyl endopeptidase (Spinacia)3 
U9G.033substance P endopeptidase (of CSF)3 
U9G.053miniglucagon endopeptidase1 
U9G.054LPXTGase (Streptococcus pyogenes) and similar4 
U9G.055D-aspartyl endopeptidase4 
U9G.060nuclear-scaffold peptidase activity9 
U9G.066cancer procoagulant1 
U9G.070salivary glutaminyl endopeptidase2 
U9G.071transthyretin5 
X42.001protease I1 
XM02.001angiotensin-converting enzyme compound peptidase26
XM12.001meprin A complex peptidase71
XM14.001metallocarboxypeptidase D compound peptidase2 
XP01.001tricorn peptidase complex14basic
XS01.001polyserase-11 
XS01.002polyserase-24 
XS01.004ovochymase (Xenopus-type)1 
XS26.001signal peptidase complex (animal)1886smallsmall
XS26.002mitochondrial signal peptidase complex1 
XS68.001PIDD auto-processing protein2 
XT01.00120S constitutive proteasome peptidase complex (eukaryote)950
XT01.00226S proteasome peptidase complex (eukaryote)139
XT01.00320 S immunoproteasome peptidase complex (eukaryote)352