$VAR1 = undef;

Summary for peptidase C19.016: ubiquitin-specific peptidase 7

Names
MEROPS Name	ubiquitin-specific peptidase 7
Other names	HAUSP, herpesvirus-associated ubiquitin-specific protease, ubiquitin-specific protease 7, USP7 g.p. (Homo sapiens), USP7

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C19 >> Subfamily (none) >> C19.016
Holotype	ubiquitin-specific peptidase 7 (Homo sapiens), Uniprot accession Q93009 (peptidase unit: 176-532), MERNUM MER0002896
History	Identifier created: MEROPS 3.1 (22 December 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00432
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Pathways	KEGG	Epstein-Barr virus infection
	KEGG	FoxO signaling pathway
	KEGG	Herpes simplex infection
	KEGG	Viral carcinogenesis
Other databases	TREEFAM	http://www.treefam.org/family/TF105667
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	L/R/G/GK/-/eg/- (based on 12 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	12	12	0	1	2	0
Pro	0	0	0	0	0	0	0	3
Ala	0	0	0	0	0	0	0	0
Val	0	0	0	0	0	1	0	0
Leu	12	0	0	0	0	0	0	0
Ile	0	0	0	0	2	2	0	0
Met	0	0	0	0	1	0	0	0
Phe	0	0	0	0	0	0	0	0
Tyr	0	0	0	0	0	0	0	1
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	0	0	0	1
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	1
Gln	0	0	0	0	0	0	0	0
Asp	0	0	0	0	0	0	0	0
Glu	0	0	0	0	0	0	4	1
Lys	0	0	0	0	9	1	0	0
Arg	0	12	0	0	0	1	1	0
His	0	0	0	0	0	1	0	0