$VAR1 = undef;

Summary for peptidase M12.225: ADAMTS5 peptidase

Names
MEROPS Name	ADAMTS5 peptidase
Other names	ADAMTS5 g.p. (Homo sapiens), ADAMTS-11 [obs.], aggrecanase-2, ADMP-2, implantin, ADAMTS-5

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.225
Holotype	ADAMTS5 peptidase (Homo sapiens), Uniprot accession Q9UNA0 (peptidase unit: 262-476), MERNUM MER0005548
History	Identifier created: MEROPS 3.4 (5 November 1999)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00198
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (29 cleavages)
Activity status	human: active (Hughes et al., 2004) mouse: active (by similarity)
Knockout	The results of experiments with a genetically modified mouse in which the catalytic domain of ADAMTS5 was deleted indicate that this peptidase is the primary "aggrecanase" responsible for aggrecan degradation in a murine model of osteoarthritis (Glasson et al., 2005). A similar conclusion was reached by Stanton et al. (2005).
Pharmaceutical relevance	ADAM-TS5 is a potential drug target for the treatment of osteoarthritis (Malfait et al., 2002; Glasson et al., 2005; Stanton et al., 2005).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/ADAMTS5
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/eal/-/g/- (based on 435 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	34	32	16	18	23	12	127	62
Pro	22	26	12	12	0	5	3	23
Ala	37	74	101	51	136	32	61	53
Val	28	31	31	6	52	47	8	32
Leu	33	46	48	15	91	62	12	26
Ile	27	21	15	3	13	53	6	23
Met	10	9	23	19	13	10	5	5
Phe	15	33	11	18	10	6	6	8
Tyr	5	32	4	24	5	9	2	6
Trp	1	4	3	2	2	1	1	4
Ser	23	14	20	19	21	22	37	28
Thr	28	19	12	7	9	41	26	16
Cys	3	0	7	6	1	7	3	4
Asn	21	15	7	13	3	11	9	8
Gln	22	12	47	25	25	20	17	25
Asp	18	7	10	7	6	10	37	42
Glu	38	27	42	177	5	13	44	47
Lys	31	14	6	1	3	5	2	1
Arg	28	15	15	5	4	63	26	11
His	11	4	5	7	13	6	3	11