Summary for peptidase M03.006: mitochondrial intermediate peptidase
| Names | |
|---|---|
| MEROPS Name | mitochondrial intermediate peptidase |
| Other names | At5g51540 (Arabidopsis thaliana)-like peptidase, DDB_G0295743 g.p. (Dictyostelium discoideum), MAL13P1.184 g.p. (Plasmodium falciparum), MIPEP g.p. (Homo sapiens), octapeptidyl aminopeptidase 1, OCT1 g.p. (Saccharomyces cerevisiae), Y67H2A.7 g.p. (Caenorhabditis elegans) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(E) >> Family M3 >> Subfamily A >> M03.006 |
| Holotype | mitochondrial intermediate peptidase (Saccharomyces cerevisiae), Uniprot accession P35999 (peptidase unit: 59-772), MERNUM MER0001156 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| Peplist | Included in the Peplist with identifier PL00141 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.59 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (1 cleavage) | ||
| Activity status | human: active (Isaya, G. et al., 1992) mouse: active (by similarity to rat) (Isaya, G. et al., 1992) | ||
| Physiology | Processing of some mitochondrial proteins during import from cytosol | ||
| Other databases | PANTHER | http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR11804:SF5 | |
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | qa/p/l/q san/Kap/v/q (based on 34 cleavages) | ||
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| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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