$VAR1 = undef;
Summary for peptidase M04.005: pseudolysin
| Names | |
|---|---|
| MEROPS Name | pseudolysin |
| Other names | elastase B (Pseudomonas aeruginosa), keratinase Ker P (Pseudomonas aeruginosa), LasB g.p. (Pseudomonas aeruginosa), Pseudomonas neutral metalloproteinase, Pseudomonas elastase, PT121 protease, solvent-stable protease (Pseudomonas aeruginosa PST-01), solvent-stable protease (Pseudomonas aeruginosa PT121), PST-01 protease (Pseudomonas aeruginosa), PseA peptidase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(E) >> Family M4 >> Subfamily (none) >> M04.005 |
| Holotype | pseudolysin (Pseudomonas aeruginosa), Uniprot accession P14756 (peptidase unit: 201-493), MERNUM MER0001024 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| Peplist | Included in the Peplist with identifier PL00145 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.26 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (24 cleavages) | ||
| Physiology | Bacterial nutrition. Role in virulence? | ||
| Pharmaceutical relevance | Work with strains of Pseudomonas aeruginosa differing in secretion of pseudolysin, in a mouse model of diffuse panbronchiolitis, indicated that the enzyme is a potent inflammatory factor, leading the authors to suggest that control of release of pseudolysin by P. aeruginosa may be beneficial for patients with this condition (Yanagihara et al., 2003). | ||
| Other databases | PANTHER | http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR33794:SF1 | |
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | -/-/-/g Lfiv/a/-/- (based on 70 cleavages) | ||
 |
| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
