$VAR1 = undef;

Summary for peptidase C04.004: tobacco etch virus NIa peptidase

Names
MEROPS Name	tobacco etch virus NIa peptidase
Other names	TEV protease, tobacco etch virus NIa protease

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(C) >> Family C4 >> Subfamily (none) >> C04.004
Holotype	tobacco etch virus NIa peptidase, Uniprot accession P04517 (peptidase unit: 2036-2279), MERNUM MER0000799
History	Identifier created: MEROPS 5.3 (4 December 2000)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00088
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (6 cleavages)
Biotechnology	The tobacco etch virus NIa endopeptidase has a sequence specificity (ENLYFQG/S ) that makes it useful in the processing of recombinant fusion proteins (Kapust et al., 2002).
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	V/RY/F/QSg/G/T/Rev (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	2	9	0	0
Pro	0	0	0	0	0	0	1	0
Ala	0	0	0	0	1	0	0	0
Val	9	1	0	0	0	0	0	2
Leu	2	0	1	0	0	1	0	0
Ile	2	0	0	0	0	0	0	0
Met	0	0	0	1	1	0	0	0
Phe	0	0	11	0	0	0	0	0
Tyr	0	6	0	0	1	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	1	0	8	0	1	0
Thr	0	0	1	0	0	0	9	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	1
Gln	0	0	0	13	0	0	0	0
Asp	0	0	0	0	0	1	1	1
Glu	0	0	0	0	0	1	0	2
Lys	1	0	0	0	0	2	2	0
Arg	0	7	0	0	0	0	0	8
His	0	0	0	0	1	0	0	0