$VAR1 = undef;

Summary for peptidase S01.033: factor VII-activating peptidase

Names
MEROPS Name	factor VII-activating peptidase
Other names	factor VII-activating protease, FSAP, HABP2 g.p. (Homo sapiens), hyaluronan-binding peptidase, hyaluronan-binding protease, hyaluronic acid-binding protease, PHBP, plasma hyaluronan-binding protein, plasma hyaluronan-binding serine protease, single-chain plasminogen activator-activating protease

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.033
Holotype	factor VII-activating peptidase (Homo sapiens), Uniprot accession Q14520 (peptidase unit: 314-557), MERNUM MER0003612
History	Identifier created: MEROPS 5.0 (17 April 2000)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00267
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Etscheid, 2004) mouse: active (by similarity to human) (Hashimoto et al., 1997)
Physiology	The Marburg I polymorphism of hyaluronan-binding peptidase (G511E) is associated with risk of cardiovascular disease (Ireland et al., 2004). This polymorphism attenuates the capacity of the enzyme to activate prourokinase (Willeit et al., 2003).
Other databases	TREEFAM	http://www.treefam.org/family/TF329901
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/k/Rsk/-/-/- (based on 15 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	1	1	0	0	0	3	3
Pro	1	1	1	0	1	1	0	0
Ala	3	0	0	0	0	0	1	0
Val	1	0	0	0	0	2	0	0
Leu	1	2	0	0	0	1	1	1
Ile	0	1	0	0	2	0	0	1
Met	0	1	0	0	0	0	0	0
Phe	0	0	2	0	0	0	1	3
Tyr	0	0	0	0	0	1	1	0
Trp	0	0	0	0	0	0	0	0
Ser	2	0	1	0	4	2	0	0
Thr	0	1	0	0	0	1	0	1
Cys	1	0	0	0	0	0	0	0
Asn	0	1	0	0	0	0	1	0
Gln	0	1	2	0	1	0	0	0
Asp	0	0	0	0	0	0	0	1
Glu	1	1	0	0	0	0	1	0
Lys	1	3	5	2	3	1	1	0
Arg	1	0	2	13	1	0	1	1
His	1	1	0	0	0	2	0	0