$VAR1 = undef;

Summary for peptidase S08.071: furin

Names
MEROPS Name	furin
Other names	dibasic processing enzyme, FURIN g.p. (Homo sapiens), Tachypleus kexin, PACE, PCSK3 peptidase, prohormone convertase, SPC1, prohormone convertase 3, proprotein convertase subtilisin/kexin type 3

Domain architecture

MEROPS Classification
Classification	Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.071
Holotype	furin (Homo sapiens), Uniprot accession P09958 (peptidase unit: 131-421), MERNUM MER0000375
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00358
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.75
Enzymology	BRENDA database
Proteolytic events	CutDB database (90 cleavages)
Activity status	human: active (Creemers & Van de Ven, 2004) mouse: active (by similarity)
Biotechnology	Proposed for use in processing of recombinant proteins.
Physiology	Processes numerous proproteins in the secretory pathway by cleavage at paired basic amino acids.
Knockout	Mouse embryos lacking furin die at about 11 days with severe heart defects (Roebroek et al., 1998).
Pathways	KEGG	Influenza A
Other databases	TREEFAM	http://www.treefam.org/family/TF314277
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	R/-/Kr/Rs/v/-/- (based on 220 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	5	2	0	17	3	21	22
Pro	1	2	10	0	2	7	11	15
Ala	4	12	9	0	25	35	13	19
Val	6	8	5	0	2	49	4	8
Leu	5	11	4	1	5	37	14	14
Ile	8	6	1	0	0	15	9	3
Met	0	2	1	0	2	1	2	5
Phe	7	6	0	0	13	6	7	5
Tyr	1	0	0	0	9	0	4	4
Trp	0	4	0	0	1	3	1	0
Ser	3	28	6	0	61	12	32	21
Thr	0	19	6	0	2	14	11	16
Cys	0	0	0	0	4	0	2	1
Asn	0	7	1	0	1	3	7	7
Gln	1	18	3	0	6	2	10	8
Asp	2	2	0	0	23	5	18	15
Glu	1	10	4	0	21	1	17	16
Lys	7	37	92	5	7	10	7	14
Arg	167	29	70	214	8	8	16	12
His	2	8	5	0	6	3	4	7