$VAR1 = undef;

Summary for peptidase C30.003: human coronavirus 229E main peptidase

Names
MEROPS Name	human coronavirus 229E main peptidase
Other names	3C-like protease, 3CLpro, Mpro, porcine epidemic diarrhea virus main peptidase

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(C) >> Family C30 >> Subfamily (none) >> C30.003
Holotype	human coronavirus 229E main peptidase, Uniprot accession Q05002 (peptidase unit: 2966-3267), MERNUM MER0002026
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00433
NC-IUBMB	Not yet included in IUBMB recommendations.
Physiology	Viral polyprotein processing in replication.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	vst/-/L/Qsa/-/-/- (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	1	3	1	0
Pro	1	0	0	0	0	0	0	0
Ala	1	1	0	0	4	3	1	1
Val	5	1	1	0	1	1	0	0
Leu	0	0	12	0	1	1	3	1
Ile	0	1	1	0	0	0	0	1
Met	0	0	0	0	0	0	0	0
Phe	0	0	0	0	0	1	0	0
Tyr	0	0	0	0	0	0	1	0
Trp	0	0	0	0	0	0	0	1
Ser	4	0	0	0	6	0	1	2
Thr	3	2	0	0	0	0	0	2
Cys	0	0	0	0	0	0	0	0
Asn	0	2	0	0	1	1	0	3
Gln	0	2	0	14	0	0	0	1
Asp	0	1	0	0	0	0	1	0
Glu	0	1	0	0	0	2	3	0
Lys	0	1	0	0	0	2	3	0
Arg	0	2	0	0	0	0	0	1
His	0	0	0	0	0	0	0	1