$VAR1 = undef;

Summary for peptidase M12.222: ADAMTS1 peptidase

Names
MEROPS Name	ADAMTS1 peptidase
Other names	ADAMTS, METH-1, KIAA1346 protein (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.222
Holotype	ADAMTS1 peptidase (Homo sapiens), Uniprot accession Q9UHI8 (peptidase unit: 253-467), MERNUM MER0005546
History	Identifier created: MEROPS 3.21 (12 May 1999)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00197
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (6 cleavages)
Activity status	human: active (Kuno, 2004) mouse: active (Russell et al., 2003)
Knockout	Forty-five percent of newborn ADAMTS1 endopeptidase null mice died, probably as a result of kidney malformation. Surviving females were subfertile (Mittaz et al., 2004).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/ADAMTS1
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/aes/-/Ela/rg/gr/- (based on 16 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	1	0	2	3	7	4
Pro	0	2	0	0	0	0	0	2
Ala	0	4	2	0	4	0	1	1
Val	4	0	0	0	0	1	0	2
Leu	2	1	1	0	6	2	0	0
Ile	2	1	0	0	0	1	0	0
Met	0	0	0	0	0	0	0	0
Phe	1	0	2	0	1	1	0	0
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	1	0	0	0	0	0
Ser	2	3	2	0	1	0	1	2
Thr	2	0	0	0	0	0	1	2
Cys	0	0	0	0	0	0	0	0
Asn	0	0	1	1	0	0	0	0
Gln	0	0	3	1	1	0	2	0
Asp	0	0	0	0	0	0	0	0
Glu	2	4	3	14	0	1	1	1
Lys	1	0	0	0	0	1	0	0
Arg	0	0	0	0	1	6	3	2
His	0	0	0	0	0	0	0	0