$VAR1 = undef;

Summary for peptidase C01.009: cathepsin V

Names
MEROPS Name	cathepsin V
Other names	cathepsin L2 (Homo sapiens), cathepsin U, CTSL2 g.p. [obs.], CTSLV g.p. (Homo sapiens), CTSV g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.009
Holotype	cathepsin V (Homo sapiens), Uniprot accession O60911 (peptidase unit: 113-334), MERNUM MER0004437
History	Identifier created: MEROPS 3.03 (10 September 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00053
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.43
Enzymology	BRENDA database
Proteolytic events	CutDB database (3 cleavages)
Pharmaceutical relevance	The activity of cathepsin V in degradation of the invariant chain of the MHC Class II complex, and its concentration in human thymic epithelial cells, suggest potential involvement in the immunopathogenesis of myasthenia gravis (Tolosa et al., 2003).
Pathways	KEGG	Lysosome
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Cathepsin_L2
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/lv/--/-/-/- (based on 5799 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	369	399	35	578	331	414	531	504
Pro	281	258	123	12	7	361	437	460
Ala	467	509	252	499	829	655	636	550
Val	398	359	1038	84	325	391	249	264
Leu	448	573	1708	320	284	234	364	221
Ile	276	300	586	52	267	371	269	266
Met	166	212	161	204	101	80	105	44
Phe	212	207	476	180	80	92	154	92
Tyr	159	140	360	143	27	54	124	54
Trp	63	51	101	55	3	13	24	14
Ser	373	352	110	430	431	437	278	314
Thr	254	268	162	481	332	346	246	263
Cys	96	79	107	97	60	34	36	22
Asn	213	245	29	169	249	216	242	238
Gln	280	262	93	390	289	253	292	249
Asp	248	213	41	182	280	349	354	674
Glu	449	390	107	496	601	546	519	736
Lys	514	567	142	823	1076	776	788	724
Arg	378	313	131	512	163	113	90	67
His	120	88	37	92	59	59	56	38

Specificity from combinatorial peptides

Organism	comment	P4	P3	P2	P1	P1'	P2'	P3'	P4'	optimal substrate	fluorophore or acceptor-donor pair	Reference
Homo sapiens	recombinant	-	A/G/H	L	R	V	I/V	-	-	xALRVIxx	Abz-EDDnp	Puzer et al., 2004
Homo sapiens	recombinant	H/broad	n/P	W/Y/L/F	R/K	-	-	-	-	HnWR	ACC	Choe et al., 2006

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
CTSV	9q22.2		ENSG00000136943	1515	CTSL2	603308