$VAR1 = undef;

Summary for peptidase A01.006: chymosin

Names
MEROPS Name	chymosin
Other names	chymosin A, chymosin B, chymosin C, rennet, rennin

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.006
Holotype	chymosin (Bos taurus), Uniprot accession P00794 (peptidase unit: 61-381), MERNUM MER0000904
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00004
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.4
Enzymology	BRENDA database
Proteolytic events	CutDB database (9 cleavages)
Activity status	human: inactive (inactive (pseudogene) ) mouse: putative
Biotechnology	Used in natural and recombinant forms in the making of cheese (Hayes et al., 2002).
Physiology	Performs limited digestion of kappa-casein in neonatal gastric digestion in ungulate mammals (Trujillo et al., 1998). The human prochymosin pseudogene is on chromosome 1.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Chymosin
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	hp/lp/se/Fml/a/i/p (based on 20 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	1	0	0	1	0	0
Pro	4	4	1	0	0	1	0	8
Ala	0	0	0	1	0	8	1	0
Val	2	1	0	1	0	1	0	0
Leu	2	7	0	2	4	1	3	1
Ile	0	2	0	0	1	1	7	0
Met	0	0	0	0	5	0	1	0
Phe	0	0	0	14	3	0	1	1
Tyr	0	0	0	2	1	0	1	1
Trp	0	0	0	0	0	0	0	1
Ser	0	0	9	0	1	0	3	0
Thr	1	1	1	0	0	0	0	1
Cys	0	0	0	0	0	0	0	1
Asn	2	1	0	0	0	0	0	0
Gln	1	0	2	0	0	3	0	1
Asp	0	0	1	0	2	0	1	2
Glu	0	2	3	0	0	1	1	0
Lys	0	0	1	0	0	1	1	1
Arg	1	1	1	0	1	2	0	0
His	6	0	0	0	0	0	0	0

Mouse genetics
Gene symbol	Position	Megabases	Ensembl	Entrez gene	MGI
Cym	3:F2.3		ENSMUSG00000046213	229697	MGI:2684977