$VAR1 = undef;

Summary for peptidase C01.018: cathepsin F

Names
MEROPS Name	cathepsin F
Other names	CLN13 (Homo sapiens), CTSF g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.018
Holotype	cathepsin F (Homo sapiens), Uniprot accession Q9UBX1 (peptidase unit: 270-484), MERNUM MER0004980
History	Identifier created: MEROPS 4.0 (27 January 2000)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00057
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.41
Enzymology	BRENDA database
Activity status	human: active (Bromme, 2004) mouse: active (by similarity) (Deussing et al., 2000)
Pharmaceutical relevance	Cathepsin F is suggested to play a regulatory role in processing the invariant chain that is associated with MHC class II, and inhibiting cathepsin F activity may block MHC class II processing in macrophages (Somoza et al., 2002).
Pathways	KEGG	Lysosome
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/CTSF
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/l/--/-/-/- (based on 3406 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	172	181	53	314	90	279	281	278
Pro	167	96	88	7	2	159	232	233
Ala	297	286	407	306	557	421	342	322
Val	241	238	436	62	207	289	162	187
Leu	354	400	1023	267	190	160	233	167
Ile	159	162	249	17	172	204	136	161
Met	120	135	135	130	58	50	50	33
Phe	110	149	145	131	85	60	72	45
Tyr	79	111	60	73	48	54	70	55
Trp	37	59	8	22	1	1	1	3
Ser	180	215	178	248	296	253	173	186
Thr	189	177	176	253	149	160	110	149
Cys	42	35	107	61	27	25	27	18
Asn	108	139	28	78	154	142	172	155
Gln	187	167	73	266	175	156	181	179
Asp	103	91	20	46	134	188	213	286
Glu	239	161	77	261	286	304	276	336
Lys	323	317	81	496	724	482	649	599
Arg	209	214	34	332	30	2	7	2
His	60	53	28	36	15	11	13	6