$VAR1 = undef;

Summary for peptidase S08.039: PCSK9 peptidase

Names
MEROPS Name	PCSK9 peptidase
Other names	Mername-AA185 peptidase, NARC-1, neural apoptosis-regulated convertase 1, PC9, PCSK9 g.p. (Homo sapiens), PCSK9, proprotein convertase 9, proprotein convertase subtilisin/kexin 9

Domain architecture

MEROPS Classification
Classification	Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.039
Holotype	PCSK9 peptidase (Mus musculus), Uniprot accession Q80W65 (peptidase unit: 147-601), MERNUM MER0022415
History	Identifier created: MEROPS 6.1 (10 January 2003)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (2 cleavages)
Activity status	human: putative (Naureckiene etal, 2003) mouse: putative
Knockout	Mutations in proprotein convertase 9 have been associated with autosomal dominant hypercholesterolemia (Abifadel et al., 2003; Maxwell & Breslow, 2005).
Other databases	TREEFAM	http://www.treefam.org/family/TF106271