$VAR1 = undef;

Summary for peptidase S01.213: coagulation factor XIa

Names
MEROPS Name	coagulation factor XIa
Other names	F11 g.p. (Homo sapiens) (activated), HEMOLEVEN, plasma thromboplastin antecedent

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.213
Holotype	coagulation factor XIa (Homo sapiens), Uniprot accession P03951 (peptidase unit: 388-625), MERNUM MER0000210
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00307
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.27
Enzymology	BRENDA database
Proteolytic events	CutDB database (7 cleavages)
Activity status	human: active (Walsh, 2004) mouse: active (Gailani et al., 1997)
Physiology	Activates factor IX in contact phase of blood coagulation.
Pathways	KEGG	Complement and coagulation cascades
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Coagulation_factor_Xia
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	kd/fl/t/Rva/ve/gt/gv (based on 12 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0	0	4	5
Pro	0	0	2	0	0	0	0	0
Ala	1	0	1	0	3	0	1	0
Val	0	0	0	0	4	5	0	2
Leu	0	4	1	0	0	0	0	0
Ile	1	0	0	0	1	1	0	1
Met	0	0	0	0	0	0	0	0
Phe	0	4	0	0	0	0	1	0
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	1	0	0	0	0	1
Ser	0	0	1	0	0	0	0	1
Thr	0	0	5	0	1	0	3	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	1	0
Gln	0	1	0	0	0	0	0	0
Asp	3	0	0	0	0	1	0	0
Glu	1	1	0	0	0	3	0	0
Lys	4	1	0	1	0	0	0	0
Arg	0	0	0	11	0	0	0	0
His	0	0	1	0	1	0	0	0