$VAR1 = undef;

Summary for peptidase S01.146: granzyme K

Names
MEROPS Name	granzyme K
Other names	granzyme 3, NK tryptase 2, RNK-Tryp-2, tryptase TL2, GZMK g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.146
Holotype	granzyme K (Homo sapiens), Uniprot accession P49863 (peptidase unit: 27-261), MERNUM MER0001936
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00279
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (4 cleavages)
Activity status	human: active (Babe & Schmidt, 2004) mouse: active (Wilharm et al., 1999)
Other databases	TREEFAM	http://www.treefam.org/family/TF333630
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/py/Rk-/l/-/v (based on 20 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	1	1	0	1	0	1	1
Pro	0	0	5	0	0	0	1	2
Ala	0	0	0	0	5	2	1	0
Val	1	3	0	0	0	2	0	5
Leu	1	2	0	0	1	5	3	0
Ile	0	0	0	0	0	2	0	0
Met	2	0	0	0	1	0	3	0
Phe	1	0	2	0	0	1	0	0
Tyr	3	1	4	0	2	0	0	0
Trp	1	0	1	0	0	0	0	0
Ser	0	1	0	0	2	0	1	0
Thr	0	1	1	0	0	1	1	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	1	0
Gln	3	4	1	0	1	1	0	0
Asp	2	2	0	0	1	0	1	2
Glu	1	0	2	0	0	0	1	1
Lys	1	1	1	4	2	1	0	1
Arg	0	1	0	16	1	0	1	0
His	0	1	0	0	1	0	0	0