Summary for peptidase S01.019: corin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates


MEROPS Namecorin
Other namesatrial natriuretic peptide-converting enzyme, heart-specific serine proteinase, low density lipoprotein receptor related protein 4, ATC2 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.019
Holotypecorin (Homo sapiens), Uniprot accession Q9Y5Q5 (peptidase unit: 802-1037), MERNUM MER0005881
History Identifier created: MEROPS 4.0 (27 January 2000)
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Wu et al., 2002)
mouse: active (Wu et al., 2002)
PhysiologyCorin is a cardiac transmembrane serine peptidase that has been shown to process pro-atrial natriuretic peptide (pro-ANP) in vitro. An allele common in blacks is associated with higher blood pressure (Dries et al., 2005).
KnockoutCorin-deficient mice develop normally during embryogenesis and survive to postnatal life. They have elevated levels of pro-atrial natriuretic peptide (ANP) but no detectable levels of ANP. They also show spontaneous hypertension. These finding indicate that corin is the physiological pro-ANP convertase (Chan et al., 2005).
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CORIN 4p13-p12 ENSG00000145244 10699 CRN 605236
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Corin 5:C3.2 ENSMUSG00000005220 53419 MGI:1349451