| Activity |
|---|
| Catalytic type | Cysteine |
| Peplist | Included in the Peplist with identifier PL00099 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.36
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (51 cleavages) |
| Activity status | human: active (Thornberry, 2004)
mouse: active (Molineaux et al., 1993)
|
| Physiology | Processes the inactive precursors of both interleukin 1-beta and interleukin 18 to the active factors. |
| Knockout | Mice deficient in the enzyme developed normally, appeared healthy, and were fertile. Apoptosis was normal or reduced according to the stimulus used (Kuida et al., 1995; Li et al., 1995). However, the mice were resistant to lipopolysaccharide-induced endotoxic shock (Li et al., 1995; Li et al., 1997), and also showed some resistance to neonatal brain damage following hypoxia and ischemia (Liu et al., 1999). Mice deficient in caspase-1 or treated with an inhibitor were protected against experimental inflammation of the intestinal mucosa (Siegmund, 2002; Loher et al., 2004). |
| Pharmaceutical relevance | Potential drug target for down-regulation of the inflammatory mediator, interleukin 1beta, which could ameliorate inflammation and endotoxic shock (Kuida et al., 1995). |
| Pathways |
KEGG | Amyotrophic lateral sclerosis (ALS) |
|
KEGG | Cytosolic DNA-sensing pathway |
|
KEGG | Influenza A |
|
KEGG | Legionellosis |
|
KEGG | NOD-like receptor signaling pathway |
|
KEGG | Pertussis |
|
KEGG | Salmonella infection |
|
Other databases
| WIKIPEDIA | http://en.wikipedia.org/wiki/Caspase_1 |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | -/-/-/D gs/-/-/- (based on 189 cleavages) |
Gxxx