$VAR1 = undef;

Summary for peptidase C19.001: ubiquitin-specific peptidase 5

Names
MEROPS Name	ubiquitin-specific peptidase 5
Other names	isopeptidase T, Ubp1 (Homo sapiens), ubiquitin-specific protease 5, USP5 g.p. (Homo sapiens), USP5

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C19 >> Subfamily (none) >> C19.001
Holotype	ubiquitin-specific peptidase 5 (Homo sapiens), Uniprot accession P45974 (peptidase unit: 288-858), MERNUM MER0002066
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00108
NC-IUBMB	3.1.2.15
Enzymology	BRENDA database
Activity status	human: active (Wilkinson, 2004) mouse: active (Hemelaar et al., 2004)
Physiology	Recycling of ubiquitin in ubiquitin-dependent proteolysis.
Other databases	TREEFAM	http://www.treefam.org/family/TF300576
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	L/R/G/Gk/-/-/- (based on 10 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	10	10	0	0	0	0
Pro	0	0	0	0	0	0	0	0
Ala	0	0	0	0	0	0	0	0
Val	0	0	0	0	0	0	0	0
Leu	9	1	0	0	0	0	2	0
Ile	0	0	0	0	0	1	1	0
Met	0	0	0	0	1	0	0	0
Phe	0	0	0	0	0	0	0	1
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	0	0	1	0
Thr	0	0	0	0	0	1	0	2
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	0	0	2	1	0
Asp	0	0	0	0	0	0	0	1
Glu	0	0	0	0	0	1	0	1
Lys	0	0	0	0	4	0	0	0
Arg	0	9	0	0	0	0	0	0
His	0	0	0	0	0	0	0	0