Summary for peptidase S01.194: complement component C2a

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namecomplement component C2a
Other namescomplement component 2 (activated), component 2 of classical-complement-pathway C3/C5 convertase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.194
Holotypecomplement component C2a (Homo sapiens), Uniprot accession P06681 (peptidase unit: 453-707), MERNUM MER0000231
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (5 cleavages)
Activity statushuman: active (Kerr, 2004)
mouse: active
PhysiologyActs in classical pathway of complement activation as component of C3/C5 convertase.
Pathways KEGGComplement and coagulation cascades
KEGGPertussis
KEGGStaphylococcus aureus infection
KEGGSystemic lupus erythematosus
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Complement_component_2
TREEFAMhttp://www.treefam.org/family/TF330194
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR19325:SF387
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
C2 6p21.3 ENSG00000180165 717 C2 217000
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
C2 17:B1 ENSMUSG00000024372 12263 MGI:88226