Summary for peptidase M17.001: leucyl aminopeptidase 3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma


MEROPS Nameleucyl aminopeptidase 3
Other namescytosol aminopeptidase, cytosolic Cys-Gly dipeptidase, HlLAP (Haemaphysalis longicornis), LAP3 g.p. (Homo sapiens), Lap3 g.p. (Mus musculus), leucyl aminopeptidase, leucyl peptidase, peptidase S, PEPS
Domain architecture
MEROPS Classification
Classification Clan MF >> Subclan (none) >> Family M17 >> Subfamily (none) >> M17.001
Holotypeleucyl aminopeptidase 3 (Bos taurus), Uniprot accession P00727 (peptidase unit: 33-519), MERNUM MER0001235
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00224
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase
EnzymologyBRENDA database
Activity statushuman: active (Strater & Lipscomb, 2004)
mouse: active (by similarity to rat) (Josch et al., 2003)
PhysiologyLikely role in cytoplasmic degradation of oligopeptides.
Pathways KEGGGlutathione metabolism
Other databases WIKIPEDIA
Relevant inhibitors amastatin, bestatin
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
LAP3 4p15.33 ENSG00000002549 51056 LAP3 170250
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Lap3 5:B3 ENSMUSG00000039682 66988 MGI:1914238