$VAR1 = undef;

Summary for peptidase C01.074: CPB peptidase

Names
MEROPS Name	CPB peptidase
Other names	cathepsin L-like protease (Leishmania donovani), CPB protease, lmcpb g.p. (Leishmania mexicana), lmajl g.p. (Leishmani major), lpcys2 g.p. (Leishmania pifanoi)

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.074
Holotype	CPB peptidase (Leishmania mexicana), Uniprot accession P36400 (peptidase unit: 125-341), MERNUM MER0000668
History	Identifier created: MEROPS 5.61 (29 October 2001)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00070
NC-IUBMB	Not yet included in IUBMB recommendations.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/K/L/RF/S/K/Q (based on 17 cleavages)

Specificity matrix

Amino acid	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0	0	0
Pro	0	0	0	0	1	1	0
Ala	1	0	0	2	1	1	0
Val	0	0	0	0	0	0	0
Leu	0	16	0	1	0	0	0
Ile	0	0	0	0	0	0	0
Met	0	0	0	0	0	0	0
Phe	1	1	0	14	1	0	0
Tyr	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0
Ser	0	0	0	0	12	0	0
Thr	0	0	0	0	0	0	0
Cys	0	0	1	0	0	0	0
Asn	0	0	0	0	0	0	0
Gln	0	0	0	0	0	0	16
Asp	0	0	0	0	0	0	0
Glu	0	0	0	0	0	0	0
Lys	13	0	1	0	0	13	0
Arg	1	0	14	0	1	1	0
His	0	0	1	0	0	0	0

Specificity from combinatorial peptides

Organism	comment	P4	P3	P2	P1	P1'	P2'	P3'	P4'	optimal substrate	fluorophore or acceptor-donor pair	Reference
Leishmania mexicana	recombinant	-	-	-	Iaf/Amf	-	-	-	-	xxxIafxxxx	Abz-EDDnp	Alves et al., 2001
Leishmania mexicana	recombinant	E/K/P	R/K	L	R/K	R	R	R	K	ERLRRRRK	Tyr(NO2)-Abz	St Hilaire et al., 2000
Leishmania mexicana	recombinant	P/H	K	L	R	-	-	-	-	PKLR	ACC	Choe et al., 2006