$VAR1 = undef;

Summary for peptidase M12.136: leucolysin

Names
MEROPS Name	leucolysin
Other names	Agkistrodon piscivorus leucostoma venom endopeptidase, Leucostoma neutral proteinase, Leucostoma peptidase A, piscivorase

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.136
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.6
Enzymology	BRENDA database
Physiology	Likely role in snake venom toxicity. Hemorrhagic. Disrupts vascular basement membrane.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Gf/-/-/- (based on 16 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	1	1	9	0	0	2	0
Pro	0	0	0	0	0	0	0	1
Ala	0	0	0	1	0	0	0	1
Val	1	2	0	0	1	1	0	1
Leu	2	0	0	1	3	0	1	0
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	0	0	2	4	1	0	1
Tyr	0	0	0	0	3	2	1	0
Trp	0	0	0	1	1	0	0	0
Ser	0	0	1	0	0	0	0	1
Thr	0	0	0	0	0	0	1	1
Cys	0	0	0	0	0	0	0	0
Asn	0	1	0	0	0	1	0	0
Gln	0	0	1	0	0	0	1	0
Asp	0	0	0	0	0	0	0	0
Glu	1	1	1	0	1	0	1	0
Lys	0	0	0	0	2	0	0	0
Arg	0	1	1	0	1	1	0	0
His	0	0	0	2	0	0	0	1