$VAR1 = undef;

Summary for peptidase C04.003: tobacco vein mottling virus-type NIa peptidase

Names
MEROPS Name	tobacco vein mottling virus-type NIa peptidase
Other names	tobacco vein mottling virus-type NIa protease, watermelon mosaic mottling virus NIa protease, soybean mosaic virus NIa protease

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(C) >> Family C4 >> Subfamily (none) >> C04.003
Holotype	tobacco vein mottling virus-type NIa peptidase, Uniprot accession P09814 (peptidase unit: 2000-2242), MERNUM MER0000798
History	Identifier created: MEROPS 5.3 (4 December 2000)

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (4 cleavages)
Biotechnology	The tobacco vein mottling virus endopeptidase is a close relative of tobacco etch virus NIa endopeptidase with a distinct sequence specificity (ETVRFQG/S) that may make it useful in the processing of recombinant fusion proteins (Nallamsetty et al., 2004).
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	V/R/F/QS/G/T/R (based on 13 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	1	8	0	0
Pro	0	0	0	0	0	0	0	0
Ala	0	0	0	0	1	0	0	0
Val	13	0	0	0	0	0	0	1
Leu	0	0	0	0	0	2	0	0
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	1	0	0	0
Phe	0	0	12	0	0	0	0	0
Tyr	0	0	0	0	1	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	8	0	1	0
Thr	0	0	1	0	0	0	9	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	13	0	0	0	0
Asp	0	0	0	0	0	1	1	0
Glu	0	0	0	0	0	2	0	1
Lys	0	0	0	0	0	0	1	0
Arg	0	13	0	0	0	0	0	9
His	0	0	0	0	1	0	0	0