| Activity |
|---|
| Catalytic type | Cysteine |
| Peplist | Included in the Peplist with identifier PL00062 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.27
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (22 cleavages) |
| Activity status | human: active (Kirschke, 2004)
mouse: active (Mason et al., 2001)
|
| Physiology | Likely roles are in lysosomal proteolysis, extracellular proteolysis including elastin degradation, and the MHC class II immune response. Cathespin S has been proposed to be involved in angiogenesis (Shi et al., 2003) and atherogenesis (Sukhova et al., 2003). |
| Knockout | Antisense-mediated down-regulation of expression of cathepsin S has implicated the enzyme in degradation of rod outer segments by retinal pigment epithelial cells. The effect might have been direct, or through an alteration in cathepsin D activity (Rakoczy et al., 1998). |
| Pharmaceutical relevance | Has strong elastinolytic activity, even at neutral pH, and may play a role in tissue damage associated with inflammation (Kirschke et al., 1989; Shi et al., 1992). Facilitates antigen presentation in the MHC class II system by degradation of the invariant chain (Driessen et al., 1999), and may therefore by a target for attenuation of immune response. |
| Pathways |
KEGG | Antigen processing and presentation |
|
KEGG | Lysosome |
|
KEGG | Phagosome |
|
KEGG | Tuberculosis |
|
Other databases
| WIKIPEDIA | http://en.wikipedia.org/wiki/Cathepsin_S |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | -/-/lv/- -/-/-/- (based on 3126 cleavages) |
LEKx