| Activity |
|---|
| Catalytic type | Metallo |
| Peplist | Included in the Peplist with identifier PL00134 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.15 (Peptidyl-dipeptidases) >> Peptidase 3.4.15.1
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (1 cleavage) |
| Activity status | human: active (Araujo et al., 2000)
mouse: active (Vazeux et al., 2001)
|
| Physiology | This is the more C-terminal peptidase unit of the two peptidase units in the somatic form of angiotensin-converting enzyme, and is the sinngle peptidase unit in the germinal form of the enzyme. Angiotensin-converting enzyme is an ectoenzyme active in the conversion of angiotensin I to hypertensive angiotensin II, and degradation of bradykinin and other bioactive peptides. An insertion/deletion polymorphism is associated with left ventricular hypertrophy. |
| Knockout | Mice in which the germinal form of angiotensin-converting enzyme is entirely secreted have low blood pressure, renal vascular thickening, and a urine concentrating defect (Esther et al., 1997), similarly to mice completely lacking angiotensin-converting enzyme (Esther et al., 1996). |
| Pharmaceutical relevance | The somatic form of angiotensin-converting enzyme containing this peptidase unit together with peptidase unit 1 (M02.001) is a drug target for the control of hypertension. |
|
Other databases
| TREEFAM | http://www.treefam.org/family/TF312861 |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | -/v/hfrsv/- -/-/-/- (based on 13 cleavages) |
