$VAR1 = undef;
Summary for peptidase S01.193: complement component activated C1s
| Names | |
|---|---|
| MEROPS Name | complement component activated C1s |
| Other names | calcium-dependent serine proteinase, C1 esterase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.193 |
| Holotype | complement component activated C1s (Homo sapiens), Uniprot accession P09871 (peptidase unit: 438-682), MERNUM MER0000239 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| Peplist | Included in the Peplist with identifier PL00301 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.42 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (3 cleavages) | ||
| Activity status | human: active (Arlaud, 2004) mouse: active (by similarity) | ||
| Inhibitors | Not trapped by alpha-2-macroglobulin (Barrett 1981). | ||
| Physiology | Contributes to classical pathway of activation of complement as component of C1, by cleavage of C4 and C2. | ||
| Pathways | KEGG | Complement and coagulation cascades | |
| KEGG | Pertussis | ||
| KEGG | Staphylococcus aureus infection | ||
| KEGG | Systemic lupus erythematosus | ||
| Other databases | TREEFAM | http://www.treefam.org/family/TF330373 | |
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | syg/Lv/Gaq/R -/L/-/vi (based on 20 cleavages) | ||
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| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| C1S | 12p13 | ENSG00000182326 | 716 | C1S | 120580 | |
