$VAR1 = undef;

Summary for peptidase M01.010: cytosol alanyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Names
MEROPS Name	cytosol alanyl aminopeptidase
Other names	aminopeptidase III, aminopeptidase PS, aminopolypeptidase, arylamidase, cytosol aminopeptidase III, enkephalin-degrading aminopeptidase, human liver aminopeptidase, meiotic prophase aminopeptidase (Arabidopsis thaliana), MPA1 (Arabidopsis thaliana), MP100 brain metalloprotease, PAM-1 aminopeptidase (Caenorhabditis elegans), puromycin-sensitive aminopeptidase, soluble alanyl aminopeptidase, thiol-activated aminopeptidase

Names

MEROPS Name

cytosol alanyl aminopeptidase

Other names

aminopeptidase III, aminopeptidase PS, aminopolypeptidase, arylamidase, cytosol aminopeptidase III, enkephalin-degrading aminopeptidase, human liver aminopeptidase, meiotic prophase aminopeptidase (Arabidopsis thaliana), MPA1 (Arabidopsis thaliana), MP100 brain metalloprotease, PAM-1 aminopeptidase (Caenorhabditis elegans), puromycin-sensitive aminopeptidase, soluble alanyl aminopeptidase, thiol-activated aminopeptidase

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.010
Holotype	cytosol alanyl aminopeptidase (Homo sapiens), Uniprot accession P55786 (peptidase unit: 268-501), MERNUM MER0002746
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00128
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.14
Enzymology	BRENDA database
Activity status	human: active (Dando & Barrett, 2004) mouse: active (Osada et al., 1999)
Physiology	Contributes to the cytosolic oligopeptides, and to the late stages of processing of antigenic peptides for the MHC class I system (Levy et al., 2002). A role in the degradation of enkephalins has been proposed.
Knockout	Mice deficient in the enzyme showed dwarfism, a marked increase in anxiety, and an analgesic effect. A variety of neurological abnormalities caused both males and females to be infertile (Osada et al., 1999; ; Osada et al., 2001a; Osada et al., 2001b).
Other databases	TREEFAM	http://www.treefam.org/family/TF300395
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/qklq/Q/Q/Q (based on 57 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	2	3	2	0	0
Pro	0	0	0	1	0	0	0	0
Ala	0	1	0	6	1	0	1	0
Val	0	0	0	0	0	0	0	1
Leu	0	0	0	10	4	1	0	1
Ile	0	0	1	1	0	1	0	0
Met	0	0	0	1	0	1	0	1
Phe	0	0	0	4	2	2	2	0
Tyr	0	0	0	3	0	0	0	0
Trp	0	0	0	0	3	0	0	0
Ser	0	0	0	0	2	0	0	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	1	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	11	14	17	19	19
Asp	0	0	0	0	0	0	0	0
Glu	0	0	0	1	1	1	0	0
Lys	0	0	0	10	5	1	0	0
Arg	1	0	0	6	3	1	0	0
His	0	0	0	0	0	0	0	0

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
NPEPPS	17q12-q21		ENSG00000141279	9520	NPEPPS	606793