$VAR1 = undef;

Summary for peptidase M12.033: LAST_MAM peptidase (Limulus-type)

Names
MEROPS Name	LAST_MAM peptidase (Limulus-type)
Other names	Limulus astacin containing a MAM domain

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily A >> M12.033
Holotype	LAST_MAM peptidase (Limulus-type) (Limulus polyphemus) (peptidase unit: 58-242), MERNUM MER0150126
History	Identifier created: MEROPS 8.3 (22 December 2008)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/-daeg/p/-/- (based on 432 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	27	38	17	21	58	20	26	37
Pro	22	42	19	49	2	130	53	25
Ala	50	41	47	53	86	48	64	44
Val	35	35	35	2	8	29	49	43
Leu	28	35	51	26	5	14	39	32
Ile	12	37	15	1	6	16	35	22
Met	11	10	14	14	8	5	12	7
Phe	13	13	22	19	1	13	11	15
Tyr	8	10	9	27	2	11	3	7
Trp	1	2	2	5	1	8	1	1
Ser	44	29	23	22	40	17	24	23
Thr	18	28	28	4	15	11	27	30
Cys	6	5	16	8	1	6	1	2
Asn	13	14	10	13	7	13	10	25
Gln	18	19	41	22	12	15	17	10
Asp	27	16	22	47	105	14	9	28
Glu	41	26	46	56	67	43	25	40
Lys	28	7	4	11	2	6	7	18
Arg	15	8	4	17	3	3	3	4
His	13	15	7	15	3	10	16	19