$VAR1 = undef;

Summary for peptidase S01.017: kallikrein-related peptidase 5

Names
MEROPS Name	kallikrein-related peptidase 5
Other names	kallikrein 5, KLK5 g.p. (Homo sapiens), KLK-L2 [obs.] g.p. (Homo sapiens), kallikrein hK5, kallikrein-like protein 2, stratum corneum tryptic enzyme, kallikrein 5 (Mus musculus)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.017
Holotype	kallikrein-related peptidase 5 (Homo sapiens), Uniprot accession Q9Y337 (peptidase unit: 67-292), MERNUM MER0005544
History	Identifier created: MEROPS 3.4 (5 November 1999)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (20 cleavages)
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/KLK5
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Rkg-/-/-/g (based on 75 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	8	9	6	5	7	3	15	18
Pro	7	1	13	0	0	3	5	5
Ala	5	2	3	2	6	2	2	4
Val	2	4	2	0	4	12	3	1
Leu	8	2	6	0	6	14	2	6
Ile	7	0	1	0	16	9	2	5
Met	1	0	0	0	0	1	1	0
Phe	2	5	5	1	2	4	1	2
Tyr	0	1	0	0	3	2	3	0
Trp	0	0	0	0	0	0	1	0
Ser	4	9	13	0	6	6	5	3
Thr	4	7	5	0	2	3	1	4
Cys	1	2	0	1	1	0	3	1
Asn	2	3	3	0	3	0	3	2
Gln	6	7	3	0	2	0	2	1
Asp	7	4	7	2	5	2	4	5
Glu	3	5	2	0	2	3	7	2
Lys	2	4	1	15	5	3	4	2
Arg	1	5	3	49	0	1	3	3
His	0	1	2	0	0	2	3	0

Specificity from combinatorial peptides

Organism	comment	P4	P3	P2	P1	P1'	P2'	P3'	P4'	optimal substrate	fluorophore or acceptor-donor pair	Reference
Homo sapiens	recombinant	Y/G	R/K	F/N/S/A	R	-	-	-	-	YRFR	ACC	Borgo�o et al., 2007
Homo sapiens	recombinant	broad	broad	S/A/T/N	R	-	-	-	-	bbSR	ACC	Debela et al., 2006

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
KLK5	19q13.3-q13.4		ENSG00000167754	25818	KLK5	605643