$VAR1 = undef;

Summary for peptidase S01.244: kallikrein-related peptidase 8

Names
MEROPS Name	kallikrein-related peptidase 8
Other names	bsp1 (Rattus norvegicus), kallikrein 8, kallikrein-8 (Homo sapiens), kallikrein hK8, kallikrein-related peptidase 8, KLK8 g.p. (Homo sapiens), neuropsin, ovasin, PRSS19 [obs.] g.p. (Homo sapiens), Prss19 g.p. (Mus musculus), TADG-14, tumor-associated differentially expressed gene 14

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.244
Holotype	kallikrein-related peptidase 8 (Mus musculus), Uniprot accession Q61955 (peptidase unit: 85-309), MERNUM MER0003631
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00325
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.118
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Kishi & Diamandis, 2004) mouse: active (Kato et al., 2001)
Physiology	Neuropsin is essential for early processes of memory acquisition in mice (Tamura et al., 2005).
Knockout	Work with neuropsin knockout mice suggested that the enzyme is involved in connectivity of certain synapses and consequently in the hippocampal networking (Hirata et al., 2001). The enzyme seems to play a role in limiting neuronal hyperexcitability induced by epileptogenic insult (Davies et al., 2001).
Pharmaceutical relevance	Neuropsin appears to be a key protein controlling pathogenic events in the hippocampus, and thus neuropsin is a potential drug target for epilepsy (Momota et al., 1998). The enzyme has been found to be strongly over-expressed in cervical and ovarian carcinomas, so may be of diagnostic value (Kishi et al., 2003; Cane et al., 2004).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/KLK8
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/RIa/vi/gn/G (based on 25 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	2	3	0	0	1	5	8
Pro	1	1	5	0	0	0	0	0
Ala	3	0	0	0	2	1	0	1
Val	0	2	1	0	0	4	1	0
Leu	0	3	2	0	1	0	0	0
Ile	3	0	0	0	7	3	0	1
Met	0	0	0	0	0	0	0	0
Phe	0	1	2	0	0	1	0	0
Tyr	0	0	0	0	0	0	0	1
Trp	0	0	0	0	0	0	0	0
Ser	1	2	5	0	0	0	0	0
Thr	1	1	3	0	1	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	1	0	0	0	2	0
Gln	0	4	0	0	0	0	1	0
Asp	0	3	0	0	0	0	0	0
Glu	1	3	0	0	0	0	0	0
Lys	0	0	1	4	0	1	1	0
Arg	0	0	2	21	0	0	0	0
His	0	0	0	0	0	0	1	0