Summary for peptidase S21.001: assemblin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma


MEROPS Nameassemblin
Other namesherpes simplex virus endopeptidase, HSV-1, HSV-2, pseudorabies virus assemblin, UL26 g.p. (herpes simplex virus), VP24
Domain architecture
MEROPS Classification
Classification Clan SH >> Subclan (none) >> Family S21 >> Subfamily (none) >> S21.001
Holotypeassemblin (human herpesvirus 2), Uniprot accession P89449 (peptidase unit: 7-247), MERNUM MER0001378
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00386
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
PhysiologyPlays essential role in assembly of herpes virions by digesting scaffold protein.
Pharmaceutical relevancePotential target for antiviral drug.