$VAR1 = undef;

Summary for peptidase S01.199: complement factor I

Names
MEROPS Name	complement factor I
Other names	C3bINA, complement component C3b inactivator, C3b/C4b inactivator

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.199
Holotype	complement factor I (Homo sapiens), Uniprot accession P05156 (peptidase unit: 340-576), MERNUM MER0000228
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00304
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.45
Enzymology	BRENDA database
Proteolytic events	CutDB database (7 cleavages)
Activity status	human: active (Sim, 2004) mouse: active (by similarity to human) (Jiang & Molina, 2000)
Physiology	Factor I has very restricted specificity, cleaving only complement components C3b or C4b in the presence of a cofactor such as factor H (Tsiftsoglou et al., 2005). Rare deficiency in human predisposes to bacterial infection.
Pathways	KEGG	Staphylococcus aureus infection
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Complement_factor_I