$VAR1 = undef;
Summary for U49.001: Lit peptidase
| Names | |
|---|---|
| MEROPS Name | Lit peptidase |
| Other names | e14 g.p. (Escherichia coli), Lit protease (Escherichia coli) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan (unassigned) >> Subclan (none) >> Family U49 >> Subfamily (none) >> U49.001 |
| Holotype | Lit peptidase (Escherichia coli), Uniprot accession P11072 (peptidase unit: 1-297), MERNUM MER0004305 |
| History | Identifier created: MEROPS 5.61 (29 October 2001) |
| Activity | |||
|---|---|---|---|
| Catalytic type | Peptidase of unknown catalytic type | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Proteolytic events | CutDB database (1 cleavage) | ||
| Physiology | Product of the e14 DNA element in some strains of Escherichia coli. e14 is a defective prophage that is integrated into the isocitrate dehydrogenase gene, and contains the lit gene. Acts in an 'exclusion system' that kills bacterial cells that are infected with T-even phages including T2, T4 and T6, preventing furhter replication of the phage. The transcription and translation of a short region of the major head coat protein gene late in phage infection activates proteolysis of translation elongation factor Tu (EF-Tu) by Lit protease, blocking translation and multiplication of the phage. | ||
