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Peptidase

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MEROPS SUBMISSIONS

Other
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$VAR1 = undef;

Summary for peptidase M28.014: carboxypeptidase Q

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Namecarboxypeptidase Q
Other nameshemopoietic lineage switch 2 protein, liver annexin-like protein (Rattus norvegicus), LCH1 peptidase, lysosomal dipeptidase, PGCP, plasma glutamate carboxypeptidase, Ser-Met dipeptidase
Domain architecture
MEROPS Classification
Classification Clan MH >> Subclan (none) >> Family M28 >> Subfamily D >> M28.014
Holotypecarboxypeptidase Q (Homo sapiens), Uniprot accession Q9Y646 (peptidase unit: 266-472), MERNUM MER0005244
History Identifier created: MEROPS 3.30 (20 July 1999)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: active (McDonald, 2004)
mouse: putative
Other databases TREEFAMhttp://www.treefam.org/family/TF323248
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bondf/-/-/- (based on 33 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 5 2 0 0 0
Pro 0 0 0 0 0 0 0 0
Ala 0 0 0 4 3 0 0 0
Val 0 0 0 1 1 0 0 0
Leu 0 0 0 6 4 0 0 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 3 4 0 0 0
Phe 0 0 0 0 9 0 0 0
Tyr 0 0 0 1 5 0 0 0
Trp 0 0 0 0 1 0 0 0
Ser 0 0 0 7 2 0 0 0
Thr 0 0 0 1 0 0 0 0
Cys 0 0 0 1 0 0 0 0
Asn 0 0 0 0 1 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 1 0 0 0 0
Glu 0 0 0 1 0 0 0 0
Lys 0 0 0 0 0 0 0 0
Arg 0 0 0 1 0 0 0 0
His 0 0 0 1 1 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
8q22.2 ENSG00000104324 10404 PGCP
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pgcp 15:B3.2 ENSMUSG00000039007 54381 MGI:1889205  

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