$VAR1 = undef;

Summary for peptidase S01.137: granzyme C

Names
MEROPS Name	granzyme C
Other names	rat granzyme RNKP-4

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.137
Holotype	granzyme C (Mus musculus), Uniprot accession P08882 (peptidase unit: 21-248), MERNUM MER0000161
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Physiology	Proposed role in immune killing of target cells.
Other databases	TREEFAM	http://www.treefam.org/family/TF333630
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/fe/fmyl-/gs/es/v (based on 19 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	2	0	0	0	7	2	1
Pro	1	0	0	0	1	2	0	1
Ala	1	2	2	0	4	2	0	1
Val	3	1	2	0	0	0	1	5
Leu	4	1	0	3	0	0	0	0
Ile	2	2	0	0	0	0	0	0
Met	0	1	1	5	2	0	0	0
Phe	1	0	7	5	0	0	0	2
Tyr	1	0	2	4	1	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	2	1	0	0	3	3	3	1
Thr	0	1	0	0	1	2	2	1
Cys	0	2	0	0	1	0	0	0
Asn	0	0	0	2	1	0	0	0
Gln	0	1	0	0	0	0	0	1
Asp	0	2	1	0	2	2	2	0
Glu	2	1	3	0	2	1	8	4
Lys	1	1	0	0	1	0	1	2
Arg	0	1	1	0	0	0	0	0
His	0	0	0	0	0	0	0	0

Mouse genetics
Gene symbol	Position	Megabases	Ensembl	Entrez gene	MGI
Gzmc	14:C1		ENSMUSG00000015441	14940	MGI:109256