$VAR1 = undef;

Summary for peptidase S08.073: PCSK2 peptidase

Names
MEROPS Name	PCSK2 peptidase
Other names	Amontillado protein (Drosophila melanogaster), neuroendocrine convertase 2 (NEC2), PC2, SPC2, PCSK2 g.p. (Homo sapiens), proprotein convertase 2, proprotein convertase subtilisin/kexin type 2

Domain architecture

MEROPS Classification
Classification	Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.073
Holotype	PCSK2 peptidase (Homo sapiens), Uniprot accession P16519 (peptidase unit: 142-439), MERNUM MER0000377
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00360
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.94
Enzymology	BRENDA database
Proteolytic events	CutDB database (41 cleavages)
Activity status	human: active (Seidah & Chretien, 2004) mouse: active (Berman et al., 2000)
Physiology	Processes various preproteins by cleavage at paired basic amino acids.
Knockout	Knockout mice were produced by Furuta et al. (1997), and were found to be viable. Such mice were later reported to have severely abnormal processing of dynorphin peptides (Berman et al., 2000).
Other databases	TREEFAM	http://www.treefam.org/family/TF314277
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	r/-/Kr/R-/-/-/- (based on 205 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	13	0	0	15	23	31	14
Pro	4	3	9	0	6	14	11	15
Ala	4	10	6	0	20	22	7	10
Val	11	8	2	0	2	27	10	6
Leu	9	15	5	0	6	22	11	14
Ile	11	3	1	0	3	16	6	2
Met	7	3	0	0	1	2	1	8
Phe	6	6	0	1	11	5	1	19
Tyr	8	1	0	0	25	5	5	6
Trp	1	0	0	0	1	2	1	1
Ser	4	22	2	1	43	17	17	16
Thr	3	12	4	0	2	10	7	7
Cys	0	0	0	0	2	1	1	1
Asn	8	5	0	0	6	2	11	11
Gln	8	27	0	0	9	3	17	4
Asp	0	8	1	0	13	5	16	21
Glu	10	19	2	0	14	6	27	22
Lys	13	20	123	11	5	7	5	7
Arg	86	15	44	192	3	7	9	7
His	2	7	0	0	9	0	1	4