$VAR1 = undef;

Summary for peptidase M14.001: carboxypeptidase A1

Names
MEROPS Name	carboxypeptidase A1
Other names	carboxypolypeptidase, carboxypeptidase A, CPA1 g.p. (Homo sapiens), pancreatic carboxypeptidase A

Domain architecture

MEROPS Classification
Classification	Clan MC >> Subclan (none) >> Family M14 >> Subfamily A >> M14.001
Holotype	carboxypeptidase A1 (Homo sapiens), Uniprot accession P15085 (peptidase unit: 111-419), MERNUM MER0001190
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00206
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.1
Enzymology	BRENDA database
Physiology	Role in mammalian alimentary digestion.
Pathways	KEGG	Pancreatic secretion
	KEGG	Protein digestion and absorption
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Carboxypeptidase_A
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/gh/fgfl/-/-/- (based on 22 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'
Gly	0	0	5	8	0
Pro	1	1	1	1	0
Ala	0	0	0	0	1
Val	1	0	0	1	3
Leu	0	0	1	2	4
Ile	1	1	0	0	2
Met	0	0	0	0	1
Phe	1	1	1	8	7
Tyr	1	0	0	0	0
Trp	0	0	0	0	3
Ser	0	0	1	0	0
Thr	0	0	0	0	0
Cys	0	0	0	0	0
Asn	0	0	0	0	0
Gln	0	1	0	0	0
Asp	0	0	0	0	0
Glu	0	0	0	0	0
Lys	0	0	0	0	0
Arg	0	0	0	0	0
His	1	2	2	1	1