Summary for peptidase S01.001: chymotrypsin A (cattle-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namechymotrypsin A (cattle-type)
Other namesalpha chymotrypsin (Bos)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.001
Holotypechymotrypsin A (cattle-type) (Bos taurus), Uniprot accession P00766 (peptidase unit: 34-263), MERNUM MER0000002
History Identifier created: MEROPS 3.1 (22 December 1998)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00264
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.1
EnzymologyBRENDA database
Proteolytic eventsCutDB database (13 cleavages)
BiotechnologyShows promise for the synthesis of peptides in non-aqueous solvents.
PhysiologyContributes to digestion of food proteins in the mammalian intestine.
Other databases PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR24250:SF34
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/yflScissile bond-/-/-/- (based on 1059 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 125 105 110 0 87 68 111 104
Pro 69 30 76 1 8 66 74 79
Ala 132 125 91 3 91 90 82 77
Val 98 73 63 1 83 55 47 37
Leu 83 34 112 274 113 94 77 88
Ile 37 55 68 2 67 38 41 28
Met 17 23 5 41 20 17 14 12
Phe 33 19 13 281 13 36 31 30
Tyr 18 19 36 297 9 43 43 19
Trp 5 3 3 63 5 6 7 9
Ser 63 67 67 0 106 70 71 53
Thr 39 88 75 1 83 55 63 80
Cys 10 12 11 2 14 24 6 41
Asn 47 56 43 36 35 53 60 51
Gln 23 39 31 8 23 62 32 41
Asp 36 44 36 1 45 38 44 57
Glu 51 86 50 9 42 62 46 60
Lys 62 103 121 2 132 88 110 106
Arg 66 58 30 1 46 44 44 34
His 18 8 9 36 9 17 22 21