Summary for peptidase S01.156: enteropeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameenteropeptidase
Other namesenterokinase, PRSS7 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.156
Holotypeenteropeptidase (Bos taurus), Uniprot accession P98072 (peptidase unit: 801-1035), MERNUM MER0000207
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00286
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.9
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Sadler, 2004)
mouse: active (Yuan et al., 1998)
BiotechnologyReagent for cleavage of recombinant fusion proteins.
InhibitorsNot trapped by alpha-2-macroglobulin (Barrett 1981).
PhysiologyActivates trypsinogen and other pancreatic proenzymes in intestine.
KnockoutHuman enteropeptidase deficiency is a rare hereditary condition first described in 1969 (Mann & Mann, 1994).
Pharmaceutical relevancePossible role in acute pancreatitis.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Enteropeptidase
TREEFAMhttp://www.treefam.org/family/TF351678
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR44892:SF1
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternds/dg/Dey/RKScissile bond-/glv/G/gs (based on 21 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 4 0 0 1 5 14 8
Pro 0 0 0 0 0 0 0 1
Ala 1 0 1 0 3 2 1 0
Val 2 1 0 0 0 4 1 0
Leu 0 1 0 0 0 4 0 0
Ile 0 0 0 0 3 0 0 0
Met 0 0 0 0 5 2 0 0
Phe 0 0 0 0 1 0 0 0
Tyr 0 1 3 0 0 0 0 0
Trp 1 0 0 0 2 1 0 1
Ser 6 2 1 0 1 0 1 7
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 2 0 2 0
Asn 0 2 0 0 0 0 0 0
Gln 1 0 0 0 1 0 1 1
Asp 6 8 11 0 0 0 0 1
Glu 1 2 5 0 0 0 0 1
Lys 0 0 0 7 0 1 0 0
Arg 1 0 0 14 1 1 0 0
His 1 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
TMPRSS15 21q21 ENSG00000154646 5651 PRSS7 226200
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Prss7 16:C3.1 ENSMUSG00000022857 19146 MGI:1197523