$VAR1 = undef;

Summary for peptidase C01.057: vinckepain-2

Names
MEROPS Name	vinckepain-2
Other names	berghepain-2 (Plasmodium berghei), yoelipain-2 (Plasmodium yoelii )

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.057
Holotype	vinckepain-2 (Plasmodium vinckei) (peptidase unit: 247-470), MERNUM MER0020527
History	Identifier created: MEROPS 6.20 (24 March 2003)

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	DI/Vli/Lvt/Rgkdar/E/E/- (based on 28 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	6	0	0	0	0
Pro	0	0	0	0	0	1	0	0
Ala	0	0	0	0	4	0	0	0
Val	0	10	6	0	0	0	0	0
Leu	0	6	14	0	1	0	0	0
Ile	4	3	0	0	0	0	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	2	1	0	1	0	0	0
Tyr	0	0	1	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	0	0	0	0
Thr	0	0	3	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	0	0	0	0	0
Asp	4	0	0	2	0	0	0	0
Glu	0	2	0	0	0	6	7	1
Lys	0	0	0	5	0	0	0	0
Arg	0	0	0	13	2	0	0	0
His	0	0	0	0	0	0	0	0

Specificity from combinatorial peptides

Organism	comment	P4	P3	P2	P1	P1'	P2'	P3'	P4'	optimal substrate	fluorophore or acceptor-donor pair	Reference
Plasmodium berghei	recombinant	broad	V	L/V	R/K	-	-	-	-	broad-VLR	AMC	Ramjee et al., 2006
Plasmodium berghei	recombinant	-	-	L	R	A	-	-	-	xxLRAxxx	Abz-Tyr(NO2)	Ramjee et al., 2006