$VAR1 = undef;

Summary for peptidase S01.139: granzyme M

Names
MEROPS Name	granzyme M
Other names	GZMM g.p. (Homo sapiens), met-ase

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.139
Holotype	granzyme M (Rattus norvegicus), Uniprot accession Q03238 (peptidase unit: 21-252), MERNUM MER0000155
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00274
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (4 cleavages)
Activity status	human: active (Smyth, 2004) mouse: active (Kelly et al., 1996)
Other databases	TREEFAM	http://www.treefam.org/family/TF335738
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	k/-/p/L-/-/-/- (based on 1369 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	35	38	152	13	49	106	91	108
Pro	115	11	313	6	2	5	97	80
Ala	127	145	227	64	212	298	150	159
Val	62	114	75	7	67	91	77	66
Leu	119	88	92	745	45	134	70	65
Ile	53	40	22	17	51	46	40	49
Met	52	33	33	180	33	35	24	22
Phe	18	34	17	25	15	79	17	20
Tyr	14	40	25	6	20	79	25	11
Trp	6	3	2	0	1	0	4	0
Ser	37	118	68	45	244	148	130	137
Thr	29	70	48	54	91	57	56	62
Cys	9	17	10	32	42	7	11	9
Asn	14	54	17	42	79	43	30	50
Gln	123	108	52	44	59	34	69	65
Asp	6	72	17	3	49	36	137	113
Glu	25	251	85	12	65	36	175	158
Lys	412	69	84	41	207	92	127	126
Arg	72	49	23	28	13	10	14	23
His	39	15	7	4	10	18	10	31