$VAR1 = undef;

Summary for peptidase S01.152: chymotrypsin B

Names
MEROPS Name	chymotrypsin B
Other names	chymotrypsin (Homo sapiens-type), chymotrypsin 2 (Canis familiaris), CTRB1 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.152
Holotype	chymotrypsin B (Bos taurus), Uniprot accession P00767 (peptidase unit: 16-245), MERNUM MER0000004
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00282
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Graf et al., 2004) mouse: active (by similarity) (Honey et al., 1984)
Physiology	Role in intestinal digestion of food proteins in mammals.
Pathways	KEGG	Pancreatic secretion
	KEGG	Protein digestion and absorption
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Chymotrypsin_B
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	a/a/pv/fylw-/-/-/dv (based on 26 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	0	0	2	0	0	0
Pro	1	1	7	0	0	0	1	1
Ala	5	8	0	0	1	1	0	0
Val	0	0	4	0	0	0	0	3
Leu	0	1	2	6	0	2	3	0
Ile	1	0	0	0	0	0	0	0
Met	0	1	0	1	0	1	0	1
Phe	1	0	0	8	0	0	0	0
Tyr	1	0	1	7	0	0	1	0
Trp	0	0	0	3	0	0	0	0
Ser	1	0	0	0	2	0	0	0
Thr	2	1	2	0	0	2	2	2
Cys	0	1	0	0	1	0	0	0
Asn	0	0	0	1	2	0	1	0
Gln	0	0	1	0	0	1	1	0
Asp	0	1	2	0	2	1	0	3
Glu	0	0	0	0	0	1	0	0
Lys	2	2	1	0	0	1	2	1
Arg	0	2	0	0	1	0	0	0
His	1	0	1	0	0	1	0	0