$VAR1 = undef;
Summary for peptidase S01.095: vascular chymase (Rattus norvegicus)
| Names | |
|---|---|
| MEROPS Name | vascular chymase (Rattus norvegicus) |
| Other names | RVCH |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.095 |
| Holotype | vascular chymase (Rattus norvegicus) (peptidase unit: 21-246), MERNUM MER0014550 |
| History | Identifier created: MEROPS 5.61 (29 October 2001) |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Physiology | Expressed by vascular smooth muscle cells in rat. Converts angiotensin I to II. | ||
| Pharmaceutical relevance | Spontaneously hypertensive rats show elevated expression, and transgenic mice showed changes suggesting that this may be a candidate gene and a therapeutic target in patients with high blood pressure (Guo et al., 2001 ; Ju et al., 2001). | ||
