$VAR1 = undef;
Summary for peptidase M43.005: pappalysin-2
| Names | |
|---|---|
| MEROPS Name | pappalysin-2 |
| Other names | cellular repressor of E1A-stimulated genes, CREG, PAPPA2 g.p. (Homo sapiens), Mername-AA189 peptidase, pregnancy-associated plasma protein A2 |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(M) >> Family M43 >> Subfamily B >> M43.005 |
| Holotype | pappalysin-2 (Homo sapiens), Uniprot accession Q9BXP8 (peptidase unit: 614-938), MERNUM MER0014521 |
| History | Identifier created: MEROPS 6.20 (24 March 2003) |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Proteolytic events | CutDB database (1 cleavage) | ||
| Activity status | human: active (Overgaard et al., 2001) mouse: putative | ||
| Physiology | It has been suggested that 'PAPP-A2 is a likely candidate IGFBP-5 proteinase in many tissues' (Overgaard et al., 2001). | ||
| Other databases | TREEFAM | http://www.treefam.org/family/TF331636 | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| PAPPA2 | 1q23-q25 | ENSG00000116183 | 60676 | PLAC3 | ||
| Mouse genetics | ||||||
| Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
| Creg1 | 1:H2.3 | ENSMUSG00000026732 | 23850 | MGI:1344382 | ||
