$VAR1 = undef;

Summary for peptidase S01.153: elastase-1

Names
MEROPS Name	elastase-1
Other names	CELA1 g.p. (Homo sapiens), CELA g.p. (Mus musculus), CELA g.p. (Rattus norvegicus), pancreatopeptidase E, pancreatic elastase, p6-5 protein, PRT-201, vonapanitase

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.153
Holotype	elastase-1 (Sus scrofa), Uniprot accession P00772 (peptidase unit: 27-266), MERNUM MER0000142
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00283
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.36
Enzymology	BRENDA database
Proteolytic events	CutDB database (15 cleavages)
Activity status	human: active (Bieth, 2004) mouse: active (by similarity) (Honey et al., 1984)
Physiology	Role in intestinal digestion of food proteins in mammals.
Pharmaceutical relevance	Evaluated as drug target for acute pancreatitis.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Elastase
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	a/-/-/av-/-/-/- (based on 51 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	3	4	2	2	3	1	0
Pro	3	0	10	0	0	1	3	1
Ala	10	7	6	15	3	3	2	1
Val	3	4	3	11	4	2	4	1
Leu	5	3	4	6	4	6	3	4
Ile	3	0	1	3	0	0	1	0
Met	1	1	1	0	1	0	1	2
Phe	0	1	4	0	3	3	0	0
Tyr	1	2	1	3	2	3	3	1
Trp	0	0	0	0	0	0	0	0
Ser	2	5	1	4	5	1	4	6
Thr	0	3	0	4	2	1	1	3
Cys	2	3	2	1	1	2	2	3
Asn	2	1	0	0	1	2	0	1
Gln	1	1	1	1	1	3	2	0
Asp	0	0	0	0	0	0	1	0
Glu	2	5	2	0	3	2	4	7
Lys	0	0	2	0	1	0	1	0
Arg	0	1	2	0	0	1	0	2
His	0	3	2	1	1	0	1	1