Summary for peptidase S09.010: oligopeptidase B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Nameoligopeptidase B
Other namesalkaline peptidase, dipeptidyl aminopeptidase BI (Pseudomonas sp. WO24), peptidase A, oligopeptidase Tb (Trypanosoma brucei), oligopeptidase Tc (Trypanosoma congolense), oligopeptidase Tc80 (Trypanosoma cruzi), OpdB g.p. (Salmonella typhimurium), peptidase I-mes (Prosopis velutina), protease II (Escherichia coli)
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S9 >> Subfamily A >> S09.010
Holotypeoligopeptidase B (Escherichia coli), Uniprot accession P24555 (peptidase unit: 397-682), MERNUM MER0000410
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00371
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.83
EnzymologyBRENDA database
Proteolytic eventsCutDB database (8 cleavages)
Pathways KEGGAfrican trypanosomiasis
Other databases PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR11757:SF3
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/g/rgkfp/RScissile bond-/-/-/- (based on 42 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 7 6 0 2 0 0 2
Pro 1 2 4 1 1 1 0 0
Ala 1 2 0 0 0 0 0 0
Val 0 4 0 0 1 0 0 0
Leu 0 4 2 0 0 0 1 1
Ile 0 1 0 0 1 0 2 1
Met 0 0 0 0 0 0 0 0
Phe 1 2 4 1 1 0 1 1
Tyr 1 1 0 0 1 2 0 0
Trp 0 0 0 0 0 0 0 0
Ser 1 2 0 0 2 2 1 0
Thr 0 0 0 0 0 0 0 0
Cys 0 2 0 0 0 0 1 1
Asn 3 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 1 0 0 1 0 0
Glu 0 0 0 0 0 0 0 0
Lys 1 0 5 3 0 0 0 0
Arg 1 1 11 37 1 1 2 1
His 0 0 1 0 0 1 0 1
Relevant inhibitors TLCK, Z-Phe-Arg-diazomethane