$VAR1 = undef;

Summary for peptidase A01.010: cathepsin E

Names
MEROPS Name	cathepsin E
Other names	CTSE g.p. (Homo sapiens), erythrocyte membrane aspartic proteinase, gastric cathepsin, slow-moving proteinase

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.010
Holotype	cathepsin E (Homo sapiens), Uniprot accession P14091 (peptidase unit: 61-396), MERNUM MER0000944
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00008
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.34
Enzymology	BRENDA database
Proteolytic events	CutDB database (31 cleavages)
Activity status	human: active (Kay & Tatnell, 2004) mouse: active (Tatnell et al., 1997)
Physiology	Cathepsin E is an endosomal peptidase and has proposed roles in antigen presentation by the MHC class II system, through processing of both invariant chain and protein antigens (Maric et al., 1994; Chain et al., 2005).
Knockout	Mice lacking cathepsin E spontaneously develop skin lesions similar to those of humans with atopic dermatitis (Tsukuba et al., 2003).
Pharmaceutical relevance	Activity of cathepsin E seems to contribute to excitotoxin-induced neuronal cell death (Tominaga et al., 1998).
Pathways	KEGG	Lysosome
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Cathepsin_E
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/lfv/-/-/- (based on 1596 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	135	71	49	24	19	79	91	181
Pro	127	47	1	0	6	0	21	76
Ala	130	74	172	67	201	244	116	199
Val	89	167	189	14	326	211	140	102
Leu	120	161	77	646	235	140	210	131
Ile	68	108	100	14	222	103	110	74
Met	25	59	36	99	53	25	48	42
Phe	49	77	19	339	108	19	37	28
Tyr	42	49	37	81	78	24	15	36
Trp	7	15	3	13	1	0	1	1
Ser	95	89	147	24	67	132	103	96
Thr	79	101	80	23	51	127	115	107
Cys	24	24	36	32	10	34	17	21
Asn	55	49	101	14	38	34	80	72
Gln	65	68	92	22	30	92	78	87
Asp	100	123	159	39	47	83	109	78
Glu	139	153	182	134	74	143	173	119
Lys	107	86	53	3	25	96	127	131
Arg	87	52	35	7	3	9	3	2
His	44	18	26	1	0	0	0	6