$VAR1 = undef;
Summary for peptidase M01.008: pyroglutamyl-peptidase II
| Names | |
|---|---|
| MEROPS Name | pyroglutamyl-peptidase II |
| Other names | PGP-2, pyroglutamyl aminopeptidase II, thyrotropin-releasing hormone-degrading ectoenzyme, TRH-degrading ectoenzyme, thyroliberinase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.008 |
| Holotype | pyroglutamyl-peptidase II (Rattus norvegicus), Uniprot accession Q10836 (peptidase unit: 369-592), MERNUM MER0001701 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| Peplist | Included in the Peplist with identifier PL00127 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase 3.4.19.6 | ||
| Enzymology | BRENDA database | ||
| Activity status | human: active (Bauer, 2004) mouse: active (Mayas et al., 2000) | ||
| Physiology | Ectoenzyme with possible role in destruction of TRH. | ||
| Other databases | TREEFAM | http://www.treefam.org/family/TF300395 | |
