$VAR1 = undef;

Summary for peptidase C01.084: bleomycin hydrolase (animal)

Names
MEROPS Name	bleomycin hydrolase (animal)
Other names	aminopeptidase H, hydrolase H, BANA-hydrolase, BLH, BLMH g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C1 >> Subfamily B >> C01.084
Holotype	bleomycin hydrolase (animal) (Homo sapiens), Uniprot accession Q13867 (peptidase unit: 3-443), MERNUM MER0002481
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00073
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.40
Enzymology	BRENDA database
Activity status	human: active (Joshua-Tor & Johnston, 2004) mouse: active (Haston et al., 2002)
Physiology	Cytosolic aminopeptidase. Suggested to function as an MHC class I epitope-processing protease (Haston et al., 2002).
Knockout	A mouse line deficient in bleomycin hydrolase has been created, and showed that the enzyme has an important role in neonatal survival and in maintaining epidermal integrity (Schwartz et al., 1999).
Pharmaceutical relevance	Peptidase destroys chemotherapeutic bleomycin.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/BLMH
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	ek/vl/hv/-fq/ka/le/vd (based on 19 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	1	0	0	0
Pro	0	0	0	0	0	0	0	0
Ala	0	0	0	1	0	2	1	0
Val	0	3	2	1	0	0	0	3
Leu	0	2	1	3	0	0	3	0
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	1	0	0	0	0
Phe	0	0	0	2	3	1	0	0
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	0	0	0	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	1	0	0	0	0
Gln	1	0	0	0	3	0	0	0
Asp	0	0	0	0	0	0	0	2
Glu	3	0	0	1	0	0	2	1
Lys	2	1	0	0	0	3	0	0
Arg	0	0	0	3	0	0	0	0
His	0	0	3	4	0	0	0	0